Echinococcus multilocularis: the parasite-host interplay.

Experimental Parasitology
B Gottstein, A Hemphill

Abstract

Alveolar echinococcosis (AE) is a severe chronic helminthic disease caused by the intrahepatic tumor-like growth of the metacestode of Echinococcus multilocularis. Metacestodes are fluid-filled, asexually proliferating vesicles, which are entirely covered by the laminated layer, an acellular carbohydrate-rich surface structure that protects the parasite from immunological and physiological reactions on part of the host. The E. multilocularis metacestode has acquired specific means of manipulating and using the immunological host response to its own advantage. These include the expression of distinct immunoregulatory parasite molecules that manipulate and interfere in the functional activity of macrophages and T cells. Recent research findings have led to a better understanding of the protein- and glycoprotein composition of the laminated layer and the E/S fraction of the metacestode, including Em2- and Em492-antigens, two metacestode antigen fractions that exhibit immunosuppressive or -modulatory properties. Understanding of the events taking place at the host-parasite interface is the key for development of novel immuno-therapeutical and/or chemotherapeutical tools.

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Citations

Nov 24, 2011·Clinical & Developmental Immunology·Alessandra SiracusanoElena Ortona
Mar 27, 2010·Journal of Biomedicine & Biotechnology·Dominique Angèle Vuitton, Bruno Gottstein
Dec 14, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·Charlotte DentanPhilippe Gaudin
May 9, 2009·La Presse médicale·Dominique Angèle VuittonGeorges Mantion
Feb 27, 2009·The Veterinary Journal·Clément Lagrue, Robert Poulin
Feb 13, 2016·Parasite Immunology·S Mahanty
Jan 25, 2011·Trends in Parasitology·Alvaro DíazFernando Ferreira
Jul 14, 2009·Molecular and Biochemical Parasitology·Zhisheng DangChihiro Sugimoto
Apr 27, 2017·Journal of Proteomics·Karina M MonteiroHenrique B Ferreira
Feb 6, 2020·Experimental and Therapeutic Medicine·Fengming TianXiumin Ma
Feb 15, 2019·Clinical Microbiology Reviews·Hao WenDonald P McManus
Dec 21, 2019·Scientific Reports·Dominic RitlerBritta Lundström-Stadelmann
Mar 23, 2021·PLoS Neglected Tropical Diseases·Natalia MacchiaroliMara Cecilia Rosenzvit
Jun 24, 2021·Seminars in Liver Disease·Solange Bresson-HadniFrançois Chappuis

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