Echinocystic acid ameliorates lung inflammation in mice and alveolar macrophages by inhibiting the binding of LPS to TLR4 in NF-κB and MAPK pathways

Biochemical Pharmacology
Eun-Ha JohDong-Hyun Kim

Abstract

Orally administered lancemaside A, which is isolated from Codonopsis lanceolata (family Campanulaceae), showed anti-colitic effect in mice. However, its metabolite echinocystic acid was absorbed into the blood. Therefore, its anti-inflammatory effects were investigated in lipopolysaccharide (LPS)-stimulated alveolar macrophages in vitro and acute lung injury in vivo. Alveolar macrophages from mice were stimulated with LPS and were treated with echinocystic acid. Acute lung injury was induced by intratracheal administration of LPS in mice. Mice were treated with echinocystic acid or dexamethasone. Echinocystic acid potently suppressed the production of the pro-inflammatory cytokines, TNF-α and IL-1β, as well as of the activations of NF-κB and MAPKS, in LPS-stimulated alveolar macrophages. Echinocystic acid also down-regulated the production of inflammatory markers, which included inducible nitric oxide synthase and cyclooxygenase-2, as well as the inflammatory mediators, nitric oxide and prostaglandin E(2), in LPS-stimulated alveolar macrophages. Echinocystic acid also inhibited the activation of IL-1 receptor-associated kinases, and the activation of mitogen-activated protein kinases in LPS-stimulated alveolar macrophages. Furt...Continue Reading

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Citations

Nov 8, 2013·Inflammation·Chunzhen ZhaoFadi Tang
Apr 17, 2013·European Journal of Pharmacology·Peng-Jiu YuShu-Guang Wu
Aug 2, 2012·Journal of Agricultural and Food Chemistry·In-Ah LeeDong-Hyun Kim
Aug 26, 2014·International Immunopharmacology·Niu NiuHaiqing Zhang
Jun 28, 2014·European Journal of Pharmacology·Jin-Ju JeongDong-Hyun Kim
Jan 14, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaohan XuWan-Chun Sun
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Jan 29, 2013·International Immunopharmacology·Supriya R HyamDong-Hyun Kim
Mar 31, 2015·The Journal of Surgical Research·Yuexia LiHongmin Wang
Jan 27, 2015·European Journal of Pharmacology·Wang QiushiXu Guangquan
Apr 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kun-Chang WuGuan-Jhong Huang
Dec 18, 2015·International Immunopharmacology·Jing LinHuimin Yu
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Mar 10, 2017·Immunopharmacology and Immunotoxicology·Yanting WuYifei Wang

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