Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement and epidermal growth factor receptor mutation coexisting in Chinese patients with lung adenocarcinoma

Thoracic Cancer
Jianfei ZhuLanjun Zhang

Abstract

The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) rearrangement is almost in mutual exclusion to epidermal growth factor receptor (EGFR) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations, with rare exceptions. This study aimed to search for the coexisting gene alterations in Chinese patients with lung adenocarcinoma (LAC). We detected mutations in the EGFR, KRAS, and ALK gene rearrangements in samples from 131 Chinese patients with LAC. ALK rearrangements were identified by fluorescent in situ hybridization. Mutations in EGFR (exons 19 to 21) and KRAS (codons 12 and 13) were determined by real time polymerase chain reaction. All patients were classified into four distinct genotype groups: EGFR mutations (n = 63; 48.1%), ALK rearrangements (n = 9; 6.9%), KRAS mutations (n = 8; 6.1%), and the wild-type (unmutated) genotype of all three genes (WT/WT/WT) (n = 53; 40.5%). Interestingly, two never-smoking women (2/131, 1.5%) harbored coexisting ALK rearrangement and EGFR mutation. ALK rearrangement occurred more frequently in young patients (8/9) (P = 0.687), non-smokers (8/9) (P = 0.077), and those who had no family history of LAC (8/9) (P = 1.000); all KRAS mutations ...Continue Reading

References

Aug 3, 1999·Nature Biotechnology·D WhitcombeS Little
Mar 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vincent A MillerRobert T Heelan
Mar 3, 2005·Journal of the National Cancer Institute·Hisayuki ShigematsuAdi F Gazdar
Jul 15, 2005·The New England Journal of Medicine·Frances A ShepherdUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions
Jan 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kentaro InamuraYuichi Ishikawa
Sep 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gregory J RielyMarc Ladanyi
Jan 27, 2009·Cancer·Daisy Wing-Sze WongUNKNOWN University of Hong Kong Lung Cancer Study Group
Apr 8, 2009·Proceedings of the American Thoracic Society·Gregory J RielyWilliam Pao
Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leora Horn, William Pao
Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alice T ShawA John Iafrate
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka
Dec 17, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Benjamin SolomonD Ross Camidge
Dec 22, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chen MaoQing Chen
Feb 26, 2010·Annals of Surgical Oncology·Tsuyoshi TakahashiHiroshi Date
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Oct 29, 2010·The New England Journal of Medicine·Eunice L KwakA John Iafrate
Nov 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yao-Wen KuoJin-Yuan Shih
Dec 21, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M TiseoA Ardizzoni
Jun 10, 2011·Genome Research·Fabio VandinBenjamin J Raphael
Oct 19, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sanjay PopatMary E R O'Brien
Dec 8, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas J VogelzangMark G Kris
Feb 14, 2012·Nature Medicine·Doron LipsonPhilip J Stephens
Nov 17, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Gouji ToyokawaYukito Ichinose

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Citations

Sep 10, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yan WangJun Zhang

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