Echo-lucency of computerized ultrasound images of carotid atherosclerotic plaques are associated with increased levels of triglyceride-rich lipoproteins as well as increased plaque lipid content

Circulation
M L GrønholdtH Sillesen

Abstract

Echo-lucency of carotid atherosclerotic plaques on computerized ultrasound B-mode images has been associated with a high incidence of brain infarcts as evaluated on CT scans. We tested the hypotheses that triglyceride-rich lipoproteins in the fasting and postprandial state predict carotid plaque echo-lucency and that echo-lucency predicts a high plaque lipid content. The study included 137 patients with neurological symptoms and > or = 50% stenosis of the relevant carotid artery. High-resolution B-mode ultrasound images of carotid plaques were computer processed to yield a measure of echogenicity (gray-scale level). Lipoproteins were measured before and hourly for 4 hours after a standardized fatty meal. A subgroup of 58 patients underwent endarterectomy. On linear regression analysis, echo-lucency (low gray-scale level) was associated with elevated levels of fasting and postprandial plasma triglycerides (P=.0002 and P=.002), IDL cholesterol (P=.0009 and P=.006), and VLDL/chylomicron remnant cholesterol (P=.0003 and P=.0004) and triglycerides (P=.0003 and P=.003), the area under the plasma triglyceride curve 0 to 4 hours after a fatty meal (P=.001), and body mass index (P=.0001). On ANCOVA, body mass index, fasting IDL choleste...Continue Reading

References

Sep 11, 1992·American Journal of Epidemiology·S A BrownW Patsch
Dec 1, 1990·Atherosclerosis·H S SimpsonJ Shepherd
Aug 5, 1988·JAMA : the Journal of the American Medical Association·V ManninenP Koskinen
Jun 19, 1987·JAMA : the Journal of the American Medical Association·D H BlankenhornL Cashin-Hemphill
Sep 1, 1985·Archives of Surgery·J M JohnsonA Sparrow
Jul 1, 1995·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
May 1, 1995·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·N el-BarghoutyV Bahal
Aug 1, 1994·Current Opinion in Lipidology·B G Nordestgaard, L B Nielsen
Mar 1, 1994·Atherosclerosis·F KarpeA Hamsten
May 1, 1996·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·N M El-BarghoutyA Nicolaides
May 1, 1996·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·N el-BarghoutyA Androulakis

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Citations

Apr 21, 2010·Neuroradiology·Michael Rosenkranz, Christian Gerloff
Dec 5, 2003·Ultrasound in Medicine & Biology·Kendall R WatersPascal Laugier
Jul 13, 2000·Lancet·S MeairsM Hennerici
Feb 17, 2001·Ultrasound in Medicine & Biology·F RakebrandtJ P Woodcock
Oct 29, 2002·Ultrasound in Medicine & Biology·Pantelis AsvestasAndrew N Nicolaides
Oct 29, 2002·Ultrasound in Medicine & Biology·Marco RossiGino Santoro
Apr 12, 2000·Journal of the American College of Cardiology·M UraT Goto
Dec 19, 2002·Neuroimaging Clinics of North America·Marie-Louise Moes Grønholdt
Dec 17, 2008·Nature Clinical Practice. Cardiovascular Medicine·Robert S Rosenson, Bertram Pitt
Dec 3, 1999·Journal of Internal Medicine·F Karpe
Nov 11, 1999·Current Opinion in Lipidology·M EvansA Rees
Oct 21, 2006·Neurosurgery·Ricardo A HanelL Nelson Hopkins
Feb 26, 2008·AJNR. American Journal of Neuroradiology·K YoshidaS Yamagata
Jul 23, 2013·Journal of Hypertension·Sanne A E PetersUNKNOWN METEOR study group
May 18, 2010·European Journal of Pediatrics·Murat Muhtar YilmazerTalat Tavli
Sep 24, 1999·Current Medical Research and Opinion·A Mooney
Sep 10, 2003·International Journal of Cardiovascular Interventions·I Patrick KayPatrick W Serruys
Dec 24, 2013·Journal of Vascular Surgery·James PavelaJean M Panneton
Oct 27, 2010·Current Problems in Cardiology·Gerrit L ten KateArend F L Schinkel
Aug 29, 2009·Revista española de cardiología·Damian CraiemAlain Simon
Jun 19, 2007·Trends in Cardiovascular Medicine·Willem E HellingsGerard Pasterkamp
Oct 24, 2015·Ultrasound in Medicine & Biology·Simeon LechareasDespoina Perrea
Nov 23, 2006·Ultrasound in Medicine & Biology·Douglas DumontCaterina M Gallippi
Oct 4, 2012·Clinical Physiology and Functional Imaging·Mohamed YousryKenneth Caidahl
Jul 9, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Baris GuvenTaliha Oner
Jun 29, 2004·The American Journal of Cardiology·Christophe CaussinJean-François Paul
May 2, 2009·The American Journal of Cardiology·Sung-Hwan KimSeung-Jung Park
Oct 22, 2005·Revista española de cardiología·Gastón A Rodríguez-GranilloPatrick W Serruys

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