Echocardiographic abnormalities in sickle cell disease

American Journal of Hematology
Shahid AhmedLinda A Russo

Abstract

Echocardiographic abnormalities in patients with sickle cell disease (SCD) were determined, and pulmonary arterial systolic pressure (PASP) was estimated. Clinical data and echocardiograms of 38 adult hospitalized patients with SCD at two tertiary care hospitals were reviewed. Fisher's exact test was performed to determine correlation between pulmonary hypertension and various clinical variables. Pulmonary hypertension was the most common abnormality identified in 22 (58%) patients. The estimated mean PASP was 37.5 +/- 10.9 mmHg. Older age and prior history of acute chest syndrome were significantly correlated with an increased prevalence of pulmonary hypertension (P < 0.05). Patients with hemoglobin levels <8 g/dL had PASP 43.2 +/- 0.5 compared to a mean PASP of 33.3 +/- 6.0 in patients with hemoglobin > or =8 g/dL (P = 0.01). Eight (21%) patients had evidence of a hyperdynamic left ventricle. Left heart abnormalities included dilated atrium in 14 (37%), dilated ventricle in 5 (13%), ventricle hypertrophy in 5 (13%), and ventricle dysfunction in 3 (9%) patients. Right heart abnormalities included dilated atrium in 9 (24%), dilated ventricle in 6 (16%), and ventricle dysfunction in 3 (9%) patients. Despite an increased incidenc...Continue Reading

References

Jan 1, 1990·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·A L KleinJ B Seward
Dec 1, 1986·American Heart Journal·T MardelleE Bertrand
Sep 1, 1982·Archives of Internal Medicine·R H Falk, W B Hood
Jun 9, 1994·The New England Journal of Medicine·O S PlattP P Klug
Sep 15, 1994·The American Journal of Cardiology·L L SuttonJ F Lewis
Nov 1, 1996·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·D D BorgesonA J Tajik
Dec 1, 1996·Hematology/oncology Clinics of North America·O Castro
Sep 11, 1997·The New England Journal of Medicine·H F Bunn
Dec 16, 1998·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·M SanF Ba&scedil;lami&scedil;li
Dec 12, 2001·American Journal of Respiratory and Critical Care Medicine·K R Minter, M T Gladwin
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Marius M HoeperLewis J Rubin
Aug 5, 2003·Postgraduate Medical Journal·A K Siddiqui, S Ahmed

❮ Previous
Next ❯

Citations

Jun 3, 2009·Annals of Hematology·Shahla G NaomanVictor R Gordeuk
Jan 28, 2009·Clinical and Experimental Hypertension : CHE·Gamze SerarslanCenk Babayigit
Dec 11, 2007·International Journal of Cardiology·Gautam V RamaniAngel López-Candales
Feb 21, 2009·Pediatric Blood & Cancer·Robert I LiemAlexis A Thompson
Apr 30, 2013·European Journal of Haematology·Bharathi UpadhyaMary Ann Knovich
Aug 8, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Vincent AudardEmmanuelle Vermes
Sep 27, 2015·Revista brasileira de hematologia e hemoterapia·Gustavo Baptista de Almeida FaroRosana Cipolotti
Feb 11, 2015·Archives of Cardiovascular Diseases·Nadjib HammoudiFrançois Lionnet
Jan 30, 2007·Journal of the American College of Cardiology·Vandana SachdevMark T Gladwin
Jul 5, 2011·The Journal of Pediatrics·George T NicholsonLeo Lopez
May 12, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lindsay S CahillJohn G Sled
Feb 23, 2018·Congenital Heart Disease·M Louise MorrisonColin J McMahon
Mar 3, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·John Bates McCutcheonRichard Gordon
Nov 27, 2018·American Journal of Hematology·Payal C DesaiSubha Raman
Oct 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Bernardo V AlvarezJoseph R Casey
Feb 1, 2005·American Journal of Hematology·Perla VicariMaria Stella Figueiredo
Apr 30, 2017·Pediatric Blood & Cancer·Parul RaiPunam Malik
Jun 21, 2019·Cardiology in the Young·Jennifer H KleinCraig Sable
Mar 8, 2021·Journal of Thrombosis and Thrombolysis·Oluwabukola Temitope GbotoshoPunam Malik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.