Echocardiographic and cardiac Doppler assessment of mice

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
C PollickR A Kloner

Abstract

Recent studies have suggested that intermediate-frequency M-Mode transthoracic echocardiographic imaging is a promising method for evaluating the left ventricle in transgenic mice. However, there is a paucity of data regarding two-dimensional (2-D) echocardiography and cardiac Doppler echocardiography in this model. Therefore we studied 15 mice (body weights 38 to 65 gm) with an ultrasound system equipped with a 9 MHz transducer. M-mode, 2-D, pulsed, and color-flow Doppler studies were performed. Mean +/- SD for septal, posterior wall, and left ventricular cavity dimensions at end diastole were the following: M-mode: 1.1 +/- 0.2, 1.0 +/- 0.2, and 3.7 +/- 0.7 mm; 2-D: 1.0 +/- 0.2, 1.1 +/- 0.3, and 3.0 +/- 0.6mm. Left ventricular fractional shortening was assessed from the M-mode echocardiogram: mean 53.7% +/- 10.7% (range 42% to 77%). 2-D assessment of left ventricular mass correlated better with left ventricular mass identified at necropsy than left ventricular mass identified by M-mode echocardiography (r = 0.70; p = 0.007 versus r = 0.07; p not significant). 2-D visualization of left ventricle, proximal aorta, and aortic and mitral valves was excellent and was obtained mainly from a "parasternal" window. Apical views were mor...Continue Reading

References

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