Echocardiographic assessment of patients receiving long-term treatment with anorexiant medications.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
R L BowenS Lehbar

Abstract

To describe the prevalence and evaluate the risk of echocardiogram-determined valvulopathy in patients who received fenfluramine and phentermine in an effort to lose weight, in comparison with normal control subjects. A historical cohort study was conducted in a clinical obesity-management practice. A total of 164 patients (88% women) who were treated with fenfluramine-phentermine for weight loss had echocardiographic evaluations. A subsample was cross-validated. The prevalence of mild or greater aortic regurgitation was 18.3%, and the prevalence of moderate or greater mitral regurgitation was 3.7%. The prevalences of mild or greater tricuspid and pulmonary valve regurgitation, valve thickening, and pulmonary hypertension were 23.2%, 5.5%, 10.4%, and 6.7%, respectively. No significant increases in risk were found for moderate or greater regurgitation of any valve. Patients had at least a 3-fold risk for mild or greater aortic regurgitation (standardized morbidity ratio [SMR] = 3.03; 95% confidence interval [CI] = 2.05 to 4.33) and a 2-fold risk for tricuspid regurgitation (SMR = 2.24; 95% CI = 1.58 to 3.06) in comparison with normal healthy adults. Age and duration of drug therapy predicted increased risk for aortic regurgitati...Continue Reading

References

Jan 1, 1990·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·A L KleinJ B Seward
Oct 1, 1993·Annals of Internal Medicine·G A Bray
Oct 1, 1993·Annals of Internal Medicine·F X Pi-Sunyer
Aug 29, 1996·The New England Journal of Medicine·J E Manson, G A Faich
Aug 28, 1997·The New England Journal of Medicine·H M ConnollyH V Schaff
Sep 10, 1998·The New England Journal of Medicine·H JickL E Derby

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