Echocardiographic evaluation of cardiac diastolic function in patients with rheumatoid arthritis: 5 years of follow-up

Clinical Rheumatology
Dilek YaziciHaner Direskeneli

Abstract

Rheumatoid arthritis (RA) is associated with increased cardiovascular mortality. However, cardiovascular findings are mostly subtle, and diastolic function abnormalities are one of the earliest manifestations. The aim of this study was to determine diastolic function abnormalities in RA patients and to make a reevaluation of diastolic function after 5 years of follow-up. Seventy-two RA patients (mean age: 48+/-11 years, F/M: 62/10) without any known cardiac disease and 67 controls (mean age: 46+/-11 years; F/M: 53/14) were recruited. Disease activity score (DAS), lipid values, and C-reactive protein (CRP) levels were determined. Left ventricular mass, isovolumetric relaxation time, mitral annular early (E), and late (A) diastolic filling rate were determined by M-mode two-dimensional color Doppler echocardiography. Mitral annular early (E') and late (A') diastolic velocities were also evaluated by tissue Doppler echocardiography. Twenty-four RA patients were reevaluated after 5 years of follow-up with DAS, biochemical variables, and echocardiography. Fifty five of 72 (76%) RA patients and 12 of the 67 (18%) controls had diastolic dysfunction (DD). Seven of ten patients with DD at baseline continued to have DD, whereas three did...Continue Reading

References

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Citations

Sep 13, 2013·Journal of Cardiovascular Disease Research·Banerjee ArnabPalui Rajan
May 26, 2010·Annals of the Rheumatic Diseases·Kimberly P LiangSherine E Gabriel
Apr 10, 2014·Zeitschrift für Rheumatologie·A TemizH Sen
Nov 26, 2013·Rheumatic Diseases Clinics of North America·Deepali SenRichard D Brasington
Sep 25, 2012·Arthritis Care & Research·Fawad AslamMahboob Alam
Feb 10, 2011·International Journal of Rheumatic Diseases·Abo Malek Abdul MuizzHeselynn Hussein

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