Echocardiographic evaluation of cardiac function in ischemic rats: value of m-mode echocardiography

Research in Cardiovascular Medicine
Amir Darbandi AzarAnita Sadeghpour

Abstract

Echocardiography is a well-established diagnostic tool for a safe, reproducible and accurate evaluation of cardiac anatomy, hemodynamics and function in clinical practice. We sought to demonstrate the efficacy and feasibility of M-mode echocardiography to evaluate cardiac structure and function in normal and MI-induced adult rats. All animal procedures were approved by the ethics committee of Tehran University of Medical Sciences and the investigation conformed to the "Guide for the Care and Use of Laboratory Animals" published by the United States National Institutes of Health. Forty-eight male Wistar rats weighing 280-300 grams were obtained from a single breeding colony. The statistical analyses were performed using SPSS 20.0. Echocardiographic measurements were possible in all rats before and after the operation. In our survey, we studied echocardiographic alterations in rats after MI induction. Changes can be seen in all echocardiographic mean values after myocardial infarction (MI), but significant decrease (P < 0.01) of Fractional shortening and Ejection Fraction as well as significant increase (P < 0.05) of end systolic diameter and systolic volume after left anterior descending coronary artery (LAD) ligation can be goo...Continue Reading

References

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Citations

Dec 21, 2018·Journal of Applied Physiology·Dryden R BaumfalkBradley Jon Behnke
May 19, 2017·The Journal of Trauma and Acute Care Surgery·Hayley L Letson, Geoffrey P Dobson
Mar 11, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Annick Judenherc-HaouziPhilippe Haouzi

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Software Mentioned

MATLAB
SPSS Statistics

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