Abstract
Sickle cell disease (SCD) affects millions of people and causes chronic hemolytic anemia leading to vasculopathies such as pulmonary hypertension and abnormalities in cardiac function that increase complications and mortality. It is therefore crucial to identify cardiac abnormalities in SCD. We aimed to assess the prevalence of echocardiographic parameters in SCD to help identify cardiopulmonary risk. Ninety-one patients (53% male), median age of 30, body surface area (BSA) of 1.79 m2 , hemoglobin of 8.8 g/dL, and creatinine of 0.7 mg/dL identified. We retrospectively measured laboratory and echocardiographic parameters in patients with SCD : left ventricular (LV) dimensions, LV ejection fraction (LVEF), LV Myocardial Performance Index (MPI), LV Mass Index (MI), Left Atrial Volume Index (LAVI), Tricuspid Regurgitation Velocity (TRV), tricuspid annular plane systolic excursion (TAPSE), right heart dimensions. Prevalence of left heart abnormalities was 32%: increased LV end-diastolic diameter (EDD), 78%: LV MPI, 21%: diastolic dysfunction, 38%: decreased LVEF, 24%: increased LVMI, and 47%: increased LAVI. Right heart abnormalities were 39%: TAPSE, 38%: increased TRV, and 59%: increased pulmonary systolic pressure (PASP). Multivar...Continue Reading
References
Jun 1, 1976·The American Journal of Medicine·J L GerryN J Fortuin
Nov 1, 1990·Chest·L A LesterR A Arcilla
Jan 1, 1995·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·C L SimekS Kaul
Nov 15, 2000·The American Journal of Cardiology·S H PoulsenK Egstrup
Jun 26, 2001·Cardiology·J E MøllerK Egstrup
Apr 16, 2005·Heart·M KatoD Hasegawa
Feb 7, 2006·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Roberto M LangUNKNOWN European Association of Echocardiography, European Society of Cardiology
Jun 20, 2006·Journal of the American College of Cardiology·Walter P AbhayaratnaTeresa S M Tsang
Sep 26, 2006·The American Journal of Cardiology·Angel López-CandalesRaveen Bazaz
Feb 28, 2009·Journal of the National Medical Association·L Julian Haywood
Jul 14, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Lawrence G RudskiNelson B Schiller
Feb 22, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Julie BlancYounes Boudjemline
Mar 24, 2012·Journal of the American College of Cardiology·Mark T Gladwin, Vandana Sachdev
Nov 13, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Eduardo BossoneRobert Naeije
Nov 16, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Karin P Potoka, Mark T Gladwin
Feb 11, 2015·Archives of Cardiovascular Diseases·Nadjib HammoudiFrançois Lionnet
Feb 26, 2015·European Heart Journal Cardiovascular Imaging·Roberto M LangJens-Uwe Voigt
Feb 22, 2016·JACC. Cardiovascular Imaging·Omar NissMichael D Taylor
Apr 3, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehAlan D Waggoner
Jun 30, 2016·Lancet·Mark T Gladwin
Oct 12, 2016·International Journal of Cardiology·Elio AloiaSergio Mondillo