Echocardiographic predictors of mortality in patients with pulmonary hypertension and cardiopulmonary comorbidities

PloS One
Johannes SteinerGaurav Choudhary

Abstract

We aimed to identify the echocardiographic measures associated with survival in a patient population with a high prevalence of co-morbid cardiovascular and pulmonary disease that have significantly elevated estimated pulmonary artery systolic pressures (ePASP). Pulmonary hypertension (PH) is a clinical feature of several cardiopulmonary diseases that are prevalent among elderly. While certain echocardiographic parameters have been shown to be important in the prognosis in specific PH groups, the prognostic relevance of echocardiographic characteristics in a cohort with multiple cardiopulmonary comorbidities is unclear. We retrospectively identified 152 patients with ePASP > 60 mmHg by echocardiography over a five year period (6/2006-11/2011) and followed until 4/2013. Candidate clinical and echocardiographic characteristics suggestive of PH severity were compared between deceased and surviving subpopulations. Cox proportional hazard modeling was used to identify echocardiographic predictors of death adjusted for age and clinical characteristics. This was a predominantly elderly (age 78.8 ± 10.2 years), male (98.7%) cohort with several cardiopulmonary comorbidities. Overall mortality was high (69.7%, median survival 129 days). A...Continue Reading

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Citations

Aug 5, 2017·Pulmonary Circulation·Matthew JankowichGaurav Choudhary
Feb 5, 2021·Frontiers in Physiology·Jennifer KeenKurt W Prins
Mar 16, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jonathan KochavJiwon Kim

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Software Mentioned

Image J
NIH ImageJ
STATA
ePASP

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