Echocardiography, natriuretic peptides, and risk for incident heart failure in older adults: the Cardiovascular Health Study.

JACC. Cardiovascular Imaging
Andreas KalogeropoulosCardiovascular Health Study

Abstract

This study sought to examine the potential utility of echocardiography and N-terminal pro-B-type natriuretic peptide (NT-proBNP) for heart failure (HF) risk stratification in concert with a validated clinical HF risk score in older adults. Without clinical guidance, echocardiography and natriuretic peptides have suboptimal test characteristics for population-wide HF risk stratification. However, the value of these tests has not been examined in concert with a clinical HF risk score. We evaluated the improvement in 5-year HF risk prediction offered by adding an echocardiographic score and/or NT-proBNP levels to the clinical Health Aging and Body Composition (ABC) HF risk score (base model) in 3,752 participants of the CHS (Cardiovascular Health Study) (age 72.6 ± 5.4 years; 40.8% men; 86.5% white). The echocardiographic score was derived as the weighted sum of independent echocardiographic predictors of HF. We assessed changes in Bayesian information criterion (BIC), C index, integrated discrimination improvement (IDI), and net reclassification improvement (NRI). We examined also the weighted NRI across baseline HF risk categories under multiple scenarios of event versus nonevent weighting. Reduced left ventricular ejection frac...Continue Reading

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Citations

Sep 3, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Caroline M Van daeleUNKNOWN Asklepios Investigators
Mar 8, 2013·Transfusion Medicine Reviews·Asim AlamJeannie L Callum
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May 30, 2021·Journal of the American Geriatrics Society·Matthew W SegarAmbarish Pandey
Aug 18, 2021·European Journal of Preventive Cardiology·Mauro GoriMichele Senni

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