Echolucent Carotid Plaque is Associated with Future Renal Dysfunction in Patients with Stable Coronary Artery Disease

Journal of Atherosclerosis and Thrombosis
Tetsuji MochidaKiyotaka Kugiyama

Abstract

Functional and structural abnormalities of the peripheral arteries are associated with renal dysfunction, independent of the presence of renal artery stenosis. This study investigated whether echolucent carotid plaque is associated with a future decline in the renal function in patients with coronary artery disease (CAD). Ultrasound assessments of carotid plaque echolucency with integrated backscatter (IBS) analyses were performed in 327 patients with stable CAD and carotid plaque who exhibited a normal renal function (estimated glomerular filtration rate [eGFR] ≥60 mL/min/1.73 m(2)) at baseline. A lower IBS value reflects the presence of echolucent and lipid-rich unstable plaque. All patients were followed up for 36 months or until the occurrence of renal dysfunction, defined as an eGFR of <45 mL/min/1.73 m(2). During the follow-up period, 39 patients developed renal dysfunction. A multivariate logistic regression analysis showed that the presence of carotid plaque with a low IBS value was significantly associated with progression to renal dysfunction (odds ratios 0.48; 95% CI 0.30-0.78, p= 0.003). In addition, carotid plaque with a low IBS value had a significant incremental effect on the predictive value of known risk factor...Continue Reading

References

Sep 14, 1999·Circulation·P Libby, P M Ridker
Sep 28, 2000·The New England Journal of Medicine·J A GoldsteinW W O'Neill
Oct 29, 2002·Ultrasound in Medicine & Biology·Marco RossiGino Santoro
Nov 2, 2002·Nature Medicine·Peter Libby, Masanori Aikawa
Feb 5, 2003·Blood Purification·Carmine ZoccaliGiovanni Tripepi
Nov 26, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Hidehiko WakiNariaki Matsuura
May 18, 2005·Hypertension·Alejandro R ChadeLilach O Lerman
Apr 27, 2007·Journal of the American Society of Nephrology : JASN·Marc M H HermansCoen D A Stehouwer
Oct 14, 2008·Atherosclerosis·Michael G ShlipakMark J Sarnak
Dec 17, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Douglas M Silverstein
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Apr 16, 2011·Journal of the American Society of Nephrology : JASN·Marie BrietUNKNOWN Nephrotest Study Group
Jul 6, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tanvir Chowdhury TurinBrenda R Hemmelgarn
Nov 15, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Manabu UematsuKiyotaka Kugiyama

❮ Previous
Next ❯

Citations

Jan 13, 2016·Journal of Atherosclerosis and Thrombosis·Shuaibo HuangChun Liang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.