Echovirus 4 and type 1 diabetes mellitus

Autoimmunity
Oscar Diaz-HortaU Dimario

Abstract

To determine the association between exposure to enteroviruses and Type 1 diabetes. We measured neutralizing antibodies to the following enteroviruses: Coxsackievirus CA9, CB1, CB2, CB3, CB4, CB5, CB6, and Echovirus E4, E6, E9, E11 in the sera of (1) Type 1 diabetic patients at diagnosis (n = 33), (2) healthy offspring of parents with Type 1 diabetes without islet cell antibodies (ICA) (n = 43) and (3) normal controls (n = 57). All subjects were less than 20 years old. We performed the neutralization test determining the cytopathogenic effect on Vero cells. HLA DR serotyping was also performed in Group 2. Type 1 diabetic patients showed a higher frequency (21.2%, p < 0.01) of neutralizing antibodies to E4 in relation to controls (1.8%), although there were no differences comparing with offspring of Type 1 diabetic patients (20.9%). Healthy offspring carrying Type 1 diabetes HLA DR susceptibility genes were also exposed to E4 (15.0%). High frequencies of neutralizing antibodies to most enteroviruses were found in the control group. This study shows the association between Type 1 diabetes and the presence of neutralizing antibodies to Echovirus 4, suggesting the possible participation of this virus as an environmental trigger of ...Continue Reading

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Citations

May 16, 2006·Journal of Virology·Toru KannoSteven Tracy
Apr 29, 2010·Seminars in Immunopathology·Sarah J RichardsonAlan K Foulis
Mar 23, 2007·Annals of the New York Academy of Sciences·Steven Tracy, Kristen M Drescher
Oct 21, 2011·Pediatric Diabetes·Oscar Diaz-HortaAntonio Toniolo
Mar 23, 2013·Pediatric Diabetes·Maria E CraigWilliam D Rawlinson
Jan 6, 2010·Reviews in Medical Virology·S TracyK Kono
Apr 1, 2004·Endocrinology and Metabolism Clinics of North America·Heikki Hyöty
Jul 7, 2012·Cellular and Molecular Life Sciences : CMLS·Liana GhazarianAgnès Lehuen
Sep 27, 2020·Microorganisms·Abdulaziz AlhazmiDidier Hober

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