Eco-evolution of cancer resistance

Science Translational Medicine
Giannoula L Klement

Abstract

For the past 60 years, the goal of conventional cancer therapies has been the eradication of every cancer cell. To this end, patients are subjected to the highest possible doses of radiation and chemotherapy as well as radical surgeries. In the rare case in which eradication was possible, clinicians achieved long-term control of the disease. For the most part, however, upfront eradication is not possible, and despite intensive and very toxic therapies, the patient dies of the disease or of complications of therapy. As our understanding about the role of tumor microenvironment in tumor progression and drug resistance improves, we are realizing that the paradigm of killing all cancer cells may be flawed.

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Citations

Aug 2, 2016·Current Opinion in Pharmacology·Francesco Di Virgilio, Paolo Pinton
Aug 4, 2016·Endocrine-related Cancer·S LatteyerD Führer
Oct 30, 2016·Oncotarget·Edward A RietmanGiannoula Lakka Klement
May 26, 2016·Oncotarget·Giannoula Lakka KlementJaroslav Sterba
Jul 15, 2018·Nature Reviews. Cancer·Francesco Di VirgilioElena Adinolfi
Sep 29, 2017·Frontiers in Immunology·Melvin Kantono, Beichu Guo
Aug 10, 2016·Cancer Research·Vladimir L GabaiMichael Y Sherman
Jun 28, 2020·Advanced Drug Delivery Reviews·You Han Bae, Kinam Park
Aug 29, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kyoung Sub KimYou Han Bae
Mar 30, 2021·Signal Transduction and Targeted Therapy·Pian YuXiang Chen

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