Eco-friendly synthesis of gelatin-capped bimetallic Au-Ag nanoparticles for chemiluminescence detection of anticancer raloxifene hydrochloride

Luminescence : the Journal of Biological and Chemical Luminescence
Nawal A Alarfaj, Maha F El-Tohamy

Abstract

This study described the utility of green analytical chemistry in the synthesis of gelatin-capped silver, gold and bimetallic gold-silver nanoparticles (NPs). The preparation of nanoparticles was based on the reaction of silver nitrate or chlorauric acid with a 1.0 wt% aqueous gelatin solution at 50°C. The gelatin-capped silver, gold and bimetallic NPs were characterized using transmission electron microscopy, UV-vis, X-ray diffraction and Fourier transform infrared spectroscopy, and were used to enhance a sensitive sequential injection chemiluminescence luminol-potassium ferricyanide system for determination of the anticancer drug raloxifene hydrochloride. The developed method is eco-friendly and sensitive for chemiluminescence detection of the selected drug in its bulk powder, pharmaceutical injections and biosamples. After optimizing the conditions, a linear relationship in the range of 1.0 × 10(-9) to 1.0 × 10(-1)  mol/L was obtained with a limit of detection of 5.0 × 10(-10)  mol/L and a limit of quantification of 1.0 × 10(-9)  mol/L. Statistical treatment and method validation were performed based on ICH guidelines. Copyright © 2016 John Wiley & Sons, Ltd.

References

Jun 28, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jurij TronteljAles Mrhar
Jun 1, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jurij TronteljAles Mrhar
Dec 24, 2008·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Kanakapura BasavaiahKalsang Tharpa
Jun 19, 2013·Journal of Analytical Toxicology·Ting-Ting ChenMei-Chich Hsu
May 29, 2014·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·K S AbhijithM S Thakur
Mar 12, 2015·ACS Applied Materials & Interfaces·Tianyu ZhengNing Zhu

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