Ecological Drivers of Mansonella perstans Infection in Uganda and Patterns of Co-endemicity with Lymphatic Filariasis and Malaria

PLoS Neglected Tropical Diseases
Anna-Sofie StensgaardP E Simonsen

Abstract

Mansonella perstans is a widespread, but relatively unknown human filarial parasite transmitted by Culicoides biting midges. Although it is found in many parts of sub-Saharan Africa, only few studies have been carried out to deepen the understanding of its ecology, epidemiology, and health consequences. Hence, knowledge about ecological drivers of the vector and parasite distribution, integral to develop spatially explicit models for disease prevention, control, and elimination strategies, is limited. We analyzed data from a comprehensive nationwide survey of M. perstans infection conducted in 76 schools across Uganda in 2000-2003, to identify environmental drivers. A suite of Bayesian geostatistical regression models was fitted, and the best fitting model based on the deviance information criterion was utilized to predict M. perstans infection risk for all of Uganda. Additionally, we investigated co-infection rates and co-distribution with Wuchereria bancrofti and Plasmodium spp. infections observed at the same survey by mapping geographically overlapping areas. Several bioclimatic factors were significantly associated with M. perstans infection levels. A spatial Bayesian regression model showed the best fit, with diurnal temp...Continue Reading

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Nov 12, 2017·Parasites & Vectors·Abdel Jelil NjouendouSamuel Wanji
May 2, 2018·The American Journal of Tropical Medicine and Hygiene·Housseini DoloAmy D Klion
Jun 5, 2019·The American Journal of Tropical Medicine and Hygiene·Linda Batsa DebrahAchim Hoerauf
May 2, 2020·International Journal of Environmental Research and Public Health·Samuel MandaRobert Bergquist
Jun 4, 2021·Research and Reports in Tropical Medicine·Thuy-Huong Ta-TangJosé M Rubio

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Software Mentioned

Stata
Geospatial Modeling ’
ArcGIS
OpenBUGS

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