Ecologically relevant spatial memory use modulates hippocampal neurogenesis.

Proceedings. Biological Sciences
Lara D LaDageVladimir Pravosudov

Abstract

The adult hippocampus in birds and mammals undergoes neurogenesis and the resulting new neurons appear to integrate structurally and functionally into the existing neural architecture. However, the factors underlying the regulation of new neuron production is still under scrutiny. In recent years, the concept that spatial memory affects adult hippocampal neurogenesis has gained acceptance, although results attempting to causally link memory use to neurogenesis remain inconclusive, possibly owing to confounds of motor activity, task difficulty or training for the task. Here, we show that ecologically relevant, spatial memory-based experiences of food caching and retrieving directly affect hippocampal neurogenesis in mountain chickadees (Poecile gambeli). We found that restricting memory experiences in captivity caused significantly lower rates of neurogenesis, as determined by doublecortin expression, compared with captive individuals provided with such experiences. However, neurogenesis rates in both groups of captive birds were still greatly lower than those in free-ranging conspecifics. These findings show that ecologically relevant spatial memory experiences can directly modulate neurogenesis, separate from other confounds t...Continue Reading

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Citations

Jul 1, 2011·Proceedings. Biological Sciences·Timothy C RothVladimir V Pravosudov
Feb 17, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Timothy C RothVladimir V Pravosudov
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Jan 31, 2012·Brain, Behavior and Evolution·Timothy C RothVladimir V Pravosudov
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Jan 1, 2014·The European Journal of Neuroscience·Zachary J HallScott A MacDougall-Shackleton
Aug 19, 2014·The Journal of Comparative Neurology·Jacques Balthazart, Gregory F Ball
May 20, 2015·Integrative and Comparative Biology·Lara D LaDage
May 13, 2015·Integrative and Comparative Biology·Rebecca CrostonVladimir V Pravosudov
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Aug 13, 2021·Learning & Behavior·Henrik LangeTom V Smulders

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