Abstract
More than 100 years after its formal description, Chagas disease remains a major public health concern in Latin America with a yearly burden of 430,000 Disability-Adjusted Life Years (DALYs). The aetiological agent, a protozoan named Trypanosoma cruzi, is mainly transmitted to mammalian hosts by triatomine vectors. Multiple species of mammals and triatomines can harbour and transmit the parasite, and the feeding range of triatomine species typically includes many noncompetent hosts. Furthermore, the transmission of the pathogen can occur via several routes including the typical vector's faeces, but also oral, congenital and blood transfusion routes. These ecological and epidemiological complexities of the disease have hindered many control initiatives. In such a context, mathematical models provide invaluable tools to explore and understand the dynamics of T. cruzi transmission, and to design, optimize and monitor the efficacy of control interventions. We intend here to provide the first review of the mathematical models of Chagas disease, focussing on how they have contributed to our understanding of (1) the population dynamics and control of triatomine vectors, and (2) the epidemiology of T. cruzi infections. We also aim at s...Continue Reading
Citations
Sep 15, 2015·Journal of Biological Dynamics·Christopher M Kribs, Christopher Mitchell
Jul 23, 2015·Acta Tropica·Ana Maria JansenAndré Luiz R Roque
Mar 11, 2017·Epidemics·Sarah M BartschBruce Y Lee
May 21, 2015·Memórias do Instituto Oswaldo Cruz·Etienne WaleckxEric Dumonteil
May 10, 2017·PLoS Computational Biology·Nicolás TomasiniPatricio Diosque
Jul 29, 2015·European Journal of Medicinal Chemistry·Juan Carlos CoaSara M Robledo
Dec 3, 2016·PLoS Neglected Tropical Diseases·Mu-Xin ChenWei Hu
Jul 3, 2018·PLoS Neglected Tropical Diseases·Etienne WaleckxEric Dumonteil
Jul 26, 2018·Physical Chemistry Chemical Physics : PCCP·Juan Carlos CoaAlbeiro Restrepo
Apr 8, 2016·Journal of Clinical Microbiology·Alba AbrasCarmen Muñoz
Feb 13, 2016·PLoS Neglected Tropical Diseases·Julie PéneauSébastien Gourbière
Dec 5, 2018·Future Medicinal Chemistry·Mona M OkbaEssam Abdel-Sattar
Mar 9, 2018·Scientific Reports·Eric DumonteilEtienne Waleckx
Apr 11, 2019·PLoS Neglected Tropical Diseases·Matthew A DixonMaria-Gloria Basáñez
Jun 22, 2019·Parasites & Vectors·Eliana Rodríguez-MonguíZulma M Cucunubá
Dec 17, 2019·PLoS Neglected Tropical Diseases·Maria Del Pilar FernándezRicardo E Gürtler
Apr 11, 2018·Evolutionary Applications·Alheli Flores-FerrerSébastien Gourbière
Nov 30, 2019·Gates Open Research·UNKNOWN Collaborating Group on Chagas Disease Modelling
Feb 8, 2018·Memórias do Instituto Oswaldo Cruz·Elena AguileraMercedes González
Apr 12, 2018·Current Medicinal Chemistry·Elena AguileraMercedes González
Dec 1, 2019·Parasites & Vectors·Joel Israel Moo-MillanEtienne Waleckx
Jan 28, 2016·Parasites & Vectors·Zulma M CucunubáPierre Nouvellet
Oct 19, 2016·Medical and Veterinary Entomology·J A DE Fuentes-VicenteA Córdoba-Aguilar
May 22, 2019·Acta Tropica·Juliana Damieli NascimentoJoão Aristeu da Rosa