Economic analysis of rapid multiplex polymerase chain reaction testing for meningitis/encephalitis in pediatric patients

Future Microbiology
Steve DuffSamuel A Bozzette

Abstract

We assessed the possible economic impact of a rapid test in pediatric patients with suspected community-acquired meningitis/encephalitis. Modeling simulated diagnosis, clinical decisions, resource use/costs of standard of care (SOC) and two cerebrospinal fluid testing strategies using FilmArray® (FA), a US FDA-cleared system that provides results in approximately 1 h. Pathogens detected by FA caused approximately 75% of cases, 97% of which would be accurately diagnosed with FA.  Mean cost/case ranged from $17,599 to $22,025.  Syndromic testing is less expensive than SOC. Testing all suspected cases yielded greater savings ($3481/case) than testing only those with abnormal cerebrospinal fluid ($2157/case). Greater economic benefits are achievable with syndromic testing of all cases, rather than SOC or targeted syndromic testing.

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Citations

Jun 15, 2018·Expert Review of Molecular Diagnostics·Alexander L Greninger
Aug 3, 2020·Pediatric Emergency Care·Eduardo Fleischer, Paul L Aronson
Jul 20, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Lamprini PosnakoglouAthanasios Michos
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Feb 23, 2021·Biochip Journal·Hanbi KimMinhee Kang
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Methods Mentioned

BETA
PCR

Software Mentioned

Excel

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