Economic analysis of Royalactin production under uncertainty: Evaluating the effect of parameter optimization

Biotechnology Progress
Mario A Torres-AcostaNigel John Titchener-Hooker

Abstract

Royalactin is a protein with several different potential uses in humans. Research, in insects and in mammalian cells, has shown that it can accelerate cell division and prevent apoptosis. The method of action is through the use of the epidermal growth factor receptor, which is present in humans. Potential use in humans could be to lower cholesterolemic levels in blood, and to elicit similar effects to those seen in bees, e.g., increased lifespan. Mass production of Royalactin has not been accomplished, though a recent article presented a Pichia pastoris fermentation and recovery by aqueous two-phase systems at laboratory scale as a possible basis for production. Economic modelling is a useful tool with which compare possible outcomes for the production of such a molecule and in particular, to locate areas where additional research is needed and optimization may be required. This study uses the BioSolve software to perform an economic analysis on the scale-up of the putative process for Royalactin. The key parameters affecting the cost of production were located via a sensitivity analysis and then evaluated by Monte Carlo analysis. Results show that if titer is not optimized the strategy to maintain a low cost of goods is proces...Continue Reading

References

Oct 29, 1998·Cellular and Molecular Life Sciences : CMLS·J SchmitzováJ Simúth
Aug 24, 1999·Yeast·M W WertenF A de Wolf
Aug 6, 2003·Life Sciences·Iwao OkamotoMasashi Kurimoto
Mar 24, 2004·Journal of Insect Physiology·Stefan Albert, Jaroslav Klaudiny
Feb 18, 2005·Journal of Biochemistry and Molecular Biology·Chanprapa ImjongjirakSiriporn Sittipraneed
Aug 11, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Suzanne S Farid
Oct 16, 2007·Journal of Nutritional Science and Vitaminology·Hang GuoFumiki Morimatsu
Apr 26, 2011·Nature·Masaki Kamakura
Sep 13, 2011·Protein Expression and Purification·Hongbo LiDonghai Wu
Aug 29, 2012·PloS One·R Scott CornmanJay D Evans
Sep 22, 2012·Nutrition Journal·Hiroyuki MoritaTatsuo Ishizuka
Jan 1, 2012·Computational and Structural Biotechnology Journal·Michalis KoutinasAthanasios Mantalaris

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Citations

Aug 25, 2016·Biotechnology Progress·Mario A Torres-AcostaMarco Rito-Palomares
Jun 8, 2018·Biotechnology Journal·Mario A Torres-AcostaMarco Rito-Palomares
May 28, 2019·Biotechnology Progress·Mario A Torres-AcostaMarco Rito-Palomares
Mar 30, 2019·Journal of Pharmaceutical Innovation·Ou YangMarianthi Ierapetritou

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Software Mentioned

SimBioPharma
Excel
Visual Basic
BioSolve

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis