Economic evaluation for the UK of nab-paclitaxel plus gemcitabine in the treatment of metastatic pancreas cancer

British Journal of Cancer
M GharaibehI Abraham

Abstract

The combination of nab-paclitaxel plus gemcitabine (NAB-P+GEM) has shown superior efficacy over GEM monotherapy in metastatic pancreas cancer (MPC). Independent cost-effectiveness/utility analyses of NAB-P+GEM from the payer perspective have not been conducted for the UK. A Markov model simulating the health outcomes and total costs was developed to estimate the life years gained (LYG) and quality-adjusted life years gained (QALY) and incremental cost-effectiveness (ICER) and cost-utility ratios (ICUR) for patients with MPC in a base case and in a probabilistic (PSA) sensitivity analysis. Total cost included the cost of supportive care medications, administration, chemotherapy, disease monitoring, and adverse reactions; and was discounted at 3.5% per year. A full lifetime horizon and third party payer perspective was chosen. The total cost of NAB-P+GEM was £5466 higher than the cost for GEM. Respectively, LYGs were 0.97 vs 0.79 and QALYs were 0.52 vs 0.45, with ICER of £30 367/LYG and ICUR of £78 086/QALY, confirmed by PSA. The superior survival efficacy of NAB-P+GEM over GEM in the management of MPC is associated with positive cost-effectiveness and cost-utility.

References

Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Sep 16, 2004·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Hans-Georg EichlerBengt Jönsson
Nov 17, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Chris P LeeStefanos A Zenios
Apr 1, 2008·Expert Review of Pharmacoeconomics & Outcomes Research·Scott D Grosse
Dec 17, 2010·Pancreas·Timothy R Donahue, Howard A Reber
May 13, 2011·The New England Journal of Medicine·Thierry ConroyUNKNOWN PRODIGE Intergroup
Sep 8, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J M LöhrUNKNOWN CT4001 Study Group
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel D Von HoffManuel Hidalgo
Mar 8, 2013·Nature Medicine·David Holmes
Oct 18, 2013·The New England Journal of Medicine·Daniel D Von HoffMarkus F Renschler
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Aug 13, 2014·Journal of the American Society of Nephrology : JASN·Efrain ReisinMahboob Rahman
Aug 28, 2014·The New England Journal of Medicine·Peter J NeumannMilton C Weinstein
May 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J M LöhrUNKNOWN CT4001 Study Group

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Citations

Dec 29, 2016·World Journal of Gastroenterology : WJG·Marwan GhosnJoseph Kattan

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