PMID: 2120690Aug 1, 1990Paper

Economic evaluation of gastric ulcer prophylaxis in patients with arthritis receiving non-steroidal anti-inflammatory drugs

Postgraduate Medical Journal
R Knill-JonesL Davies

Abstract

This study assesses the economic benefits of misoprostol in the prophylaxis of gastric ulcers larger than 0.3 cm in patients with osteoarthritis receiving non-steroidal anti-inflammatory drugs. Independent epidemiological data were obtained for patients in Scotland and the West Midlands. Co-diagnosis of arthritis with gastric ulcer recorded in the routine data was substantially less (4% Scotland, 10% West Midlands) than the 21% found at case review. These data were combined with cost and patient management data in a decision analysis model to explore whether prophylactic use of misoprostol altered substantially the average cost of managing gastric ulcer. Using conservative assumptions and a daily dose of 400 micrograms, cost savings per patient to the National Health Service of 5-8 pounds over a 3-month period are expected in the groups of patients studied, while at the 800 micrograms dose there would be a net cost of 23-25 pounds. Sensitivity analysis showed that under many assumptions misoprostol is expected to be cost saving or cost neutral.

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Citations

Feb 1, 1997·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·S E Gabriel, J L Wagner
Aug 1, 1996·Journal of General Internal Medicine·W E SmalleyW A Ray
Apr 1, 1994·Pharmacology & Therapeutics·I Bjarnason, A J Macpherson
May 8, 1998·The American Journal of Medicine·M R Griffin
Sep 16, 2000·Journal of Pain and Symptom Management·C Hawkins, G W Hanks
Jan 5, 2002·Gastroenterology Clinics of North America·W L Straus, J J Ofman
Sep 7, 2000·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M KochL Capurso
Jul 13, 2000·The American Journal of Nursing·P M Peloso
Dec 1, 1992·Australian and New Zealand Journal of Medicine·P M Brooks, N D Yeomans
Dec 1, 1991·NLN Publications·E A Duthie, J S D'Arcangelo
Nov 12, 2013·Applied Health Economics and Health Policy·Ronald C WielageMichael Happich
Jan 1, 1992·Scandinavian Journal of Rheumatology. Supplement·H Zeidler
Jan 1, 1996·Scandinavian Journal of Rheumatology. Supplement·P M Peloso
Feb 1, 1992·Baillière's Clinical Rheumatology·P T Dawes, D P Symmons
Jun 1, 1996·Gastroenterology Clinics of North America·W E Smalley, M R Griffin
Nov 1, 2007·Current Medical Research and Opinion·Jeroen P JansenElke Hunsche
Sep 22, 2001·Best Practice & Research. Clinical Gastroenterology·M Bidaut-Russell, S E Gabriel
Jan 1, 1991·Scandinavian Journal of Gastroenterology. Supplement·R P Knill-Jones
Jun 6, 2018·Expert Review of Pharmacoeconomics & Outcomes Research·Alain Vergnenègre, Christos Chouaïd
Mar 9, 2012·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hiroshi YoshidaEiji Uchida

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