Sep 8, 2010

Economic evaluation of pneumococcal conjugate vaccination in The Gambia

BMC Infectious Diseases
Sun-Young KimSue J Goldie

Abstract

Gambia is the second GAVI support-eligible country to introduce the 7-valent pneumococcal conjugate vaccine (PCV7), but a country-specific cost-effectiveness analysis of the vaccine is not available. Our objective was to assess the potential impact of PCVs of different valences in The Gambia. We synthesized the best available epidemiological and cost data using a state-transition model to simulate the natural histories of various pneumococcal diseases. For the base-case, we estimated incremental cost (in 2005 US dollars) per disability-adjusted life year (DALY) averted under routine vaccination using PCV9 compared to no vaccination. We extended the base-case results for PCV9 to estimate the cost-effectiveness of PCV7, PCV10, and PCV13, each compared to no vaccination. To explore parameter uncertainty, we performed both deterministic and probabilistic sensitivity analyses. We also explored the impact of vaccine efficacy waning, herd immunity, and serotype replacement, as a part of the uncertainty analyses, by assuming alternative scenarios and extrapolating empirical results from different settings. Assuming 90% coverage, a program using a 9-valent PCV (PCV9) would prevent approximately 630 hospitalizations, 40 deaths, and 1000 ...Continue Reading

Mentioned in this Paper

Septicemia
Pneumococcal conjugate
Septicemia due to Streptococcus Pneumoniae
Mycoplasma pneumoniae
Haemophilus influenzae
Antibiotic throat preparations
Pathogenic Organism
Pertussis
Vaccines
Plain X-ray

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