Economic Evaluation of Stiripentol for Dravet Syndrome: A Cost-Utility Analysis

PharmacoEconomics
Jesse ElliottDoug Coyle

Abstract

Dravet syndrome is a catastrophic form of pediatric treatment-resistant epilepsy with few effective treatment options. Stiripentol is approved for use in Canada for treatment of Dravet syndrome, but the associated long-term costs and benefits have not been well-studied and its cost effectiveness is unclear. The aim of this study was to evaluate the cost effectiveness of stiripentol as an adjunctive treatment to clobazam and valproate for treatment of Dravet syndrome from the perspective of the Canadian public healthcare payer. A cost-utility analysis was performed to estimate the costs and quality-adjusted life-years (QALYs) associated with adjunctive stiripentol treatment compared with clobazam and valproate alone in children with Dravet syndrome. Transition probabilities, drug efficacy, utility weights, and costs were obtained from a review of the literature. Probabilistic analyses were conducted using a Markov model with health states related to seizure frequency. A 10-year horizon was used. The incremental cost per QALY gained (incremental cost-effectiveness ratio [ICER]) for adjunctive use of stiripentol was calculated, and assumptions were explored in scenario analyses. All costs are expressed in 2017 Canadian dollars ($C...Continue Reading

References

Aug 21, 2003·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Andrew H BriggsMartin J Price
Jan 18, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Joe T R Clarke
Dec 29, 2006·PharmacoEconomics·Rachael L Fleurence, Christopher S Hollenbeak
Aug 24, 2007·Journal of Child Neurology·Teodoro Durá-TravéFidel Gallinas-Victoriano
Jul 14, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Abbas H Panju, Chaim M Bell
Sep 9, 2010·Advances in Experimental Medicine and Biology·Christopher McCabeJeff Round
Aug 2, 2012·Thérapie·Marie-Clémence VerdierDanièle Bentué-Ferrer
Mar 30, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Don HusereauUNKNOWN CHEERS Task Force
Apr 30, 2013·Handbook of Clinical Neurology·Charlotte Dravet, Hirokazu Oguni
Jul 6, 2014·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Doug CoyleGerald A Evans
May 13, 2015·Epilepsia·Jo M WilmshurstJ Helen Cross
Oct 7, 2015·Pediatrics·Yvonne W WuMichael W Kuzniewicz
Mar 12, 2016·Paediatric Drugs·Adam WallaceDaniel L Kenney-Jung
Nov 5, 2016·Epilepsy Research·Monica S CooperIngrid E Scheffer
Jan 19, 2017·Epilepsia·Ben F M WijnenReina J A de Kinderen
Nov 17, 2017·International Journal of Technology Assessment in Health Care·Ken Bond, Laura Weeks
Feb 8, 2018·Epilepsy & Behavior : E&B·Melanie D WhittingtonJonathan D Campbell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.