Economic evaluation plan of a RCT of hydroxyapatite-coated uncemented hemiarthroplasty versus cemented hemiarthroplasty for the treatment of displaced intracapsular hip fractures: the WHiTE5 trial.

Bone & Joint Open
May E PngM L Costa

Abstract

This paper describes the methods applied to assess the cost-effectiveness of cemented versus uncemented hemiarthroplasty among hip fracture patients in the World Hip Trauma Evaluation Five (WHiTE5) trial. A within-trial cost-utility analysis (CUA) will be conducted at four months postinjury from a health system (National Health Service and personal social services) perspective. Resource use pertaining to healthcare utilization (i.e. inpatient care, physiotherapy, social care, and home adaptations), and utility measures (quality-adjusted life years) will be collected at one and four months (primary outcome endpoint) postinjury; only treatment of complications will be captured at 12 months. Sensitivity analysis will be conducted to assess the robustness of the results. The planned analysis strategy described here records our intent to conduct a within-trial CUA alongside the WHiTE5 trial.

References

Apr 12, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M HerdmanX Badia
Aug 8, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Ben van HoutA Simon Pickard
Mar 30, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Don HusereauUNKNOWN ISPOR Health Economic Evaluation Publication Guidelines-CHEERS Good Reporting Practices Task Force
Jul 28, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S WilliamsonJ Leal

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Citations

Aug 31, 2020·The Bone & Joint Journal·Nakulan Nantha KumarMichael R Whitehouse
Aug 31, 2020·The Bone & Joint Journal·Daniel C Perry, Matthew Costa

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Methods Mentioned

BETA
total hip arthroplasty

Clinical Trials Mentioned

ISRCTN18393176

Software Mentioned

R
STATA

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