Economic evaluations in rheumatoid arthritis: a critical review of measures used to define health States.

PharmacoEconomics
Nick J BansbackAslam H Anis

Abstract

We reviewed the clinical measures used in rheumatoid arthritis (RA) economic evaluations with respect to their relevance and sensitivity to changes in survival, health-related quality of life (HR-QOL) and costs. We compared the measures from the economic perspective and discussed the validity of methods used to extrapolate beyond the trial data. Cost-effectiveness evaluations of disease-modifying antirheumatic drugs in RA were identified by searching MEDLINE, EMBASE, Econlit and NHS EED databases. Studies were retained if they extrapolated beyond randomized controlled trial evidence using relationships between clinical measures, costs and utilities. In the 22 studies identified, clinical severity was measured using the Health Assessment Questionnaire (HAQ) Disability Index, the American College of Rheumatology (ACR) response criteria, the Disease Activity Score (DAS) or a combination of the HAQ and DAS. The HAQ is correlated with mortality, costs and HR-QOL instruments, and several studies used linear relationships to model these associations. However, a polynomial relationship or discrete states may be more appropriate for patients at the extremes of the disease spectrum, and numerous HAQ health states may be required to captu...Continue Reading

References

Sep 18, 2003·Arthritis and Rheumatism·Frederick Wolfe, James F Fries
Dec 21, 2004·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·G KobeltA Young
May 12, 2007·Journal of Clinical Epidemiology·C A MarraA H Anis
Sep 1, 2007·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Jonathan KarnonRon Akehurst
Jun 1, 2004·Expert Review of Pharmacoeconomics & Outcomes Research·Chiun-Fang ChiouCarolina M Reyes
Apr 1, 2007·Expert Review of Pharmacoeconomics & Outcomes Research·Jonathan Karnon

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Citations

Apr 1, 2009·International Journal of Technology Assessment in Health Care·Peter LindgrenGisela Kobelt
Sep 4, 2014·Current Rheumatology Reports·Jonathan ToshRon Akehurst
May 1, 2013·Statistics in Medicine·Sylwia BujkiewiczKeith R Abrams
May 3, 2016·Journal of Korean Medical Science·Armen Yuri GasparyanGeorge D Kitas
Sep 25, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Roberta Ara, Allan Wailoo
Dec 11, 2013·International Journal of Inflammation·Cynthia SaidAnthony Serracino Inglott
Jul 7, 2018·Current Medical Research and Opinion·Lindsay ClaxtonGene V Wallenstein
Sep 1, 2011·Rheumatology·Jonathan ToshNick Bansback
Jun 1, 2017·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Aureliano Paolo FinchClara Mukuria
May 12, 2020·PharmacoEconomics·Luiza Raquel GrazziotinDeborah A Marshall
Dec 31, 2020·Journal of Managed Care & Specialty Pharmacy·Aliza R Karpes MatusevichMaria A Lopez-Olivo

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