Economic Impact of a New Rapid PCR Assay for Detecting Influenza Virus in an Emergency Department and Hospitalized Patients

PloS One
Marcelo SotoMaría Angeles Marcos

Abstract

Seasonal influenza causes significant morbidity and mortality and has a substantial economic impact on the healthcare system. The main objective of this study was to compare the cost per patient for a rapid commercial PCR assay (Xpert® Flu) with an in-house real-time PCR test for detecting influenza virus. Community patients with influenza like-illness attending the Emergency Department (ED) as well as hospitalized patients in the Hospital Clínic of Barcelona were included. Costs were evaluated from the perspective of the hospital considering the use of resources directly related to influenza testing and treatment. For the purpose of this study, 366 and 691 patients were tested in 2013 and 2014, respectively. The Xpert® Flu test reduced the mean waiting time for patients in the ED by 9.1 hours and decreased the mean isolation time of hospitalized patients by 23.7 hours. This was associated with a 103€ (or about $113) reduction in the cost per patient tested in the ED and 64€ ($70) per hospitalized patient. Sensitivity analyses showed that Xpert® Flu is likely to be cost-saving in hospitals with different contexts and prices.

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Citations

Jan 8, 2017·Enfermedades infecciosas y microbiología clínica·José María Marimón, José María Navarro-Marí
Dec 22, 2017·Journal of Clinical Microbiology·Ferdaus HassanRangaraj Selvarangan
Dec 20, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy M UyekiAndrew T Pavia
Jan 9, 2020·Intensive Care Medicine·Antoni TorresNelson Lee
Jun 5, 2020·The Journal of Applied Laboratory Medicine·James H NicholsZahra Shajani-Yi
Apr 24, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emily R SmithManish M Patel
May 6, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly E HansonAngela M Caliendo
Dec 14, 2018·Clinical Microbiology Reviews·Carmen L CharltonSteven J Drews
Sep 25, 2020·Open Forum Infectious Diseases·Hervé JacquierEmmanuelle Cambau
Aug 25, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Andrew T RobertsBenjamin A Rogers

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Methods Mentioned

BETA
PCR

Software Mentioned

Xpert Flu
STATA

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