PMID: 9663370Jul 15, 1998Paper

Economic impact of introducing propentofylline for the treatment of dementia in Sweden

Clinical Therapeutics
Anders WimoBengt Winblad

Abstract

The purpose of this study was to estimate the impact of the introduction of propentofylline, a glial-cell modulator with neuroprotective properties, on the costs of dementia care in Sweden. To estimate the clinical effects of propentofylline treatment on dementia, we conducted a meta-analysis of four double-masked, placebo-controlled, randomized clinical trials and a simulation in a cohort of 57,000 patients with Alzheimer's disease (AD) or vascular dementia (VaD). This cohort represented the fraction of the total AD and VaD population in Sweden with mild-to-moderate disease, the target population for propentofylline treatment. The rate of progression of dementia was expressed in terms of the annual rate of change in score on the Mini-Mental State Examination (MMSE). The costs of care were estimated on the basis of a prospective population-based study. A regression model was used to quantify the costs of dementia care as a function of MMSE score. The estimates obtained were used to calculate and compare the costs of dementia care until death, with or without propentofylline treatment. The sensitivity of the results to a variety of model assumptions was also assessed. The total gross cost for 9 years under the current treatment ...Continue Reading

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Citations

May 13, 2015·International Journal of Geriatric Psychiatry·Caroline L SutcliffeDavid J Challis
Nov 1, 2015·Health Policy·Patrick BremerUNKNOWN RightTimePlaceCare Consortium
Feb 3, 2012·International Journal of Geriatric Psychiatry·Anders SköldungerKristina Johnell
Aug 18, 2009·International Journal of Geriatric Psychiatry·Erik JedeniusNiels Andreasen
Sep 15, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Larissa SchwarzkopfElmar Graessel
Jul 10, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Guk-Hee Suh
Sep 25, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Petra MennElmar Gräßel
Sep 5, 2002·International Journal of Geriatric Psychiatry·Ajit ShahGuh-Kee Suh
Sep 5, 2017·Scandinavian Journal of Caring Sciences·Christina BökbergStaffan Karlsson
Sep 21, 2018·Dementia·Sheelah Connolly
Dec 1, 2006·Alzheimer Disease and Associated Disorders·Steven H Ferris
Nov 16, 2018·International Journal of Geriatric Psychiatry·Corinna VossiusSverre Bergh
Dec 1, 2003·Expert Review of Pharmacoeconomics & Outcomes Research·Anders Wimo
Jun 1, 2008·Expert Review of Pharmacoeconomics & Outcomes Research·Mark Oremus
Jan 1, 2003·International Journal of Psychiatry in Clinical Practice·Ajit Shah, Rachel Jenkins

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