Economic implications of hepatic arterial infusion chemotherapy in treatment of nonresectable colorectal liver metastases. Meta-Analysis Group in Cancer

Journal of the National Cancer Institute
I Durand-ZaleskiP Piedbois

Abstract

Approximately 20% of patients with colorectal cancer die of metastases confined to the liver. A meta-analysis recently performed by our group confirmed that in these patients hepatic arterial infusion of 5-fluoro-2'-deoxyuridine, compared with intravenous chemotherapy with fluoropyrimidines or supportive care (including symptom palliation when necessary), improved tumor response. Because of the high cost of hepatic arterial infusion, we undertook a cost-effectiveness analysis that related the cost of such therapy to its medical efficacy. The patient population was drawn from the seven randomized clinical trials included in the meta-analysis and included individual data on 654 patients. Of these seven trials, five compared hepatic arterial infusion and intravenous chemotherapy and two compared hepatic arterial infusion and a control group in which some patients could be left untreated. Patients assigned to receive hepatic arterial infusion made up the hepatic arterial infusion group; the other patients constituted the control group. The measures of efficacy were survival and tumor response. Health-care costs (in 1995 U.S. dollars) were computed over the duration of patient follow-up and were derived from actual costs in two cent...Continue Reading

References

Jul 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P RougierD Gallot
Jun 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Nordic Gastrointestinal Tumor Adjuvant Therapy Group
Sep 14, 1991·BMJ : British Medical Journal·T G Allen-Mersh
Mar 1, 1995·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Findlay
Mar 1, 1995·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B GlimeliusP O Sjödén
Mar 15, 1995·Journal of the National Cancer Institute·S H TaplinP Nefcy
Apr 1, 1994·Medical Decision Making : an International Journal of the Society for Medical Decision Making·A S MidgetteS G Pauker
Sep 25, 1993·BMJ : British Medical Journal·R Robinson
Sep 11, 1993·BMJ : British Medical Journal·R Robinson
Mar 6, 1996·Journal of the National Cancer Institute·B F Cole
Mar 6, 1996·Journal of the National Cancer Institute·UNKNOWN Meta-Analysis Group in CancerE Levy

❮ Previous
Next ❯

Citations

Aug 15, 2006·Current Treatment Options in Oncology·Cletus A Arciero, Elin R Sigurdson
Jul 19, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R SylvesterL Duchateau
Feb 19, 1999·Journal of the American College of Surgeons·V K Sondak
Jul 11, 2000·Current Opinion in Oncology·P Piedbois, M Buyse
Mar 7, 2003·Annals of Surgical Oncology·Sarah L BlairLawrence Wagman
Jan 19, 2006·Annals of Surgical Oncology·Evan S OngN Joseph Espat
Jul 6, 2007·PharmacoEconomics·Frank G A JansmanJacobus R B J Brouwers
Apr 16, 2002·Seminars in Oncology·Don S Dizon, Nancy E Kemeny
Apr 9, 2008·Seminars in Oncology·Cletus A Arciero, Elin R Sigurdson
Oct 22, 2008·Journal of Experimental & Clinical Cancer Research : CR·Ursula AmstutzCarlo R Largiadèr
Dec 6, 2003·The Oncologist·Adam D Cohen, Nancy E Kemeny
Feb 13, 2004·Drugs & Aging·Matthew J MatasarAlfred I Neugut
Jul 25, 2008·Clinical Colorectal Cancer·Derek G PowerNancy E Kemeny

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.