PMID: 11019937Oct 6, 2000Paper

Economic outcomes associated with tricyclic antidepressant and selective serotonin reuptake inhibitor treatments for depression

Acta Psychiatrica Scandinavica. Supplementum
W H Crown

Abstract

To compare the economic outcomes associated with the tricyclic antidepressants (TCAs) and the selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression. A literature review of pertinent studies was performed. The advantages and disadvantages of clinical trials versus observational studies are described, and the breadth of the economic outcome measure chosen for the conclusions reached is discussed. The inclusion and exclusion criteria of clinical trials, in combination with their strict provider and patient study protocols, limit their generalizability to naturalistic treatment settings. Retrospective studies of patients can provide valuable information about the experiences and costs incurred by patients in actual treatment. However, confounding factors (both observable and unobservable) limit the amount of confidence that can be placed in inferences about treatment effects. Randomized prospective studies with naturalistic follow-on may help to mitigate some of the concern about treatment confounders which has traditionally been associated with non-randomized observational studies. Retrospective studies and one randomized prospective study of the economic outcomes of TCA versus SSRI treatment have found th...Continue Reading

References

Jun 26, 1996·JAMA : the Journal of the American Medical Association·G E SimonE Wagner
Nov 14, 1997·Psychiatric Services : a Journal of the American Psychiatric Association·T W CroghanD P Buesching
Apr 7, 1997·PharmacoEconomics·R L ObenchainD P Buesching
Dec 8, 1997·PharmacoEconomics·G E Simon, P Fishman
Apr 7, 1998·PharmacoEconomics·M I Wilde, P Benfield
May 6, 2006·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·J S McCombsG L Stimmel

Citations

Apr 5, 2007·Current Medical Research and Opinion·Junling WangGenene D Walker

Related Concepts

Tricyclic Antidepressive Agents
Clinical Trials
Cost Effectiveness
Melancholia
Selective Serotonin Reuptake Inhibitors

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