PMID: 3750379Jan 1, 1986Paper

Economical modification of a radioimmunoassay of digoxin with negligible interference from cord and neonatal sera

Therapeutic Drug Monitoring
H S LeeT Y Ti

Abstract

The Amerlex digoxin radioimmunoassay was modified to reduce the running cost by five times. The modified method compared well with the original method (y = 1.0138x + 0.00916, r = 0.9936). Using the modified method, the performance with the American Association for Clinical Chemistry quality control program was consistently satisfactory for 1 year. When normal cord and neonatal sera were tested with the modified method, 41% of the 22 samples of cord serum and 68% of the 19 samples of neonatal serum produced digoxin levels less than or equal to 0.05 ng/ml. The highest digoxin level produced by cord and neonatal sera was 0.3 ng/ml.

Citations

Jun 1, 1990·Journal of Paediatrics and Child Health·T Y TiC L Tan

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