Economical test methods for developmental neurobehavioral toxicity

Environmental Health Perspectives
G Bignami

Abstract

The assessment of behavioral changes produced by prenatal or early postnatal exposure to potentially noxious agents requires both the designing of ad hoc tests and the adaptation of tests for adult animals to the characteristics of successive developmental stages. The experience in designing tests is still more limited than in the adaptation of tests, but several tests have already proven their usefulness; some examples are the suckling test, the homing test, and evaluations of dam-pup and pup-pup interactions. Functional observational batteries can exploit the development at specified postnatal ages of several reflexes and responses that are absent at birth in altricial rodent species with a short pregnancy such as the rat and the mouse. In neonates, the assessment of early treatment effects can rely not only on deviations from normal responding but also on changes in the time of appearance of otherwise normal response patterns. The same applies to other end points such as responses to pain and various types of spontaneous motor/exploratory activities, including reactivity to a variety of drug challenges that can provide information on the regulatory systems whose development may be affected by early treatments. In particular,...Continue Reading

References

Apr 1, 1976·Pharmacology, Biochemistry, and Behavior·J A Hughes, Z Annau
Feb 1, 1976·Pharmacology, Biochemistry, and Behavior·I CoyleG Singer
Sep 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·G BignamiG Laviola
Aug 19, 1991·Brain Research. Developmental Brain Research·G CalamandreiE Alleva
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·G LaviolaE Alleva
Jan 1, 1991·Annual Review of Public Health·H L Needleman, D Bellinger
Nov 1, 1991·Journal of Toxicology and Environmental Health·S BeckerH S Koren
Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·S K SobrianL M Turner
May 1, 1990·Neurotoxicology and Teratology·J M DavisL D Grant
May 1, 1990·Neurotoxicology and Teratology·C D DriscollE P Riley
Sep 1, 1990·Neurotoxicology and Teratology·L P Spear
Jan 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·G R ClemensJ H Thyssen
Apr 1, 1990·Journal of Developmental and Behavioral Pediatrics : JDBP·P A Fried, B Watkinson
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·P HartleyG Vogel
Mar 1, 1990·Neurotoxicology and Teratology·J H HanniganM L Pilati
May 1, 1990·Pharmacology, Biochemistry, and Behavior·R J GruenR H Roth
Jan 1, 1989·General Pharmacology·M MargiottaC Lippe
Sep 1, 1989·Neurotoxicology and Teratology·N A ShepanekK S Allen
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·J C Tucker
Jun 10, 1988·European Journal of Pharmacology·C L Kirstein, L P Spear
Jan 1, 1987·Psychopharmacology·B ZimmerbergE P Riley
May 1, 1988·Pharmacology, Biochemistry, and Behavior·C H KinsleyR S Bridges
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G LaviolaV Cuomo
May 1, 1988·Neurotoxicology and Teratology·C R StamperL G Costa
Nov 1, 1987·Neurotoxicology and Teratology·C V Vorhees
Mar 1, 1988·Neurotoxicology and Teratology·J H Hannigan, B A Blanchard
Nov 1, 1986·The Journal of School Health·G J Botvin
Mar 1, 1987·Pharmacology, Biochemistry, and Behavior·E Alleva, G Laviola
Mar 1, 1987·Behavioral and Neural Biology·J H HanniganE P Riley

❮ Previous
Next ❯

Citations

Apr 1, 1996·Environmental Health Perspectives·B KuligD Peakall
Apr 1, 2009·Environmental Health : a Global Access Science Source·Aldina VenerosiGemma Calamandrei
Aug 10, 1999·Neurotoxicology and Teratology·G CalamandreiE Alleva
Nov 14, 2000·Brain Research·G A MetzK Fouad
Dec 2, 1999·Neuroscience and Biobehavioral Reviews·P PalanzaF S vom Saal
Jun 9, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Addolorata ColucciaMaria Rosaria Carratù
Jul 1, 2009·Environmental Toxicology and Pharmacology·Kristin I FolvenAnne-Katrine Lundebye
Nov 27, 2007·Neuroscience and Biobehavioral Reviews·Jirí SedýEva Syková
Dec 5, 2006·Neurotoxicology·Diane S RohlmanLinda McCauley
Jun 19, 2004·Neurotoxicology and Teratology·Philip W DavidsonGregory E Wilding
Jan 21, 2015·Nutritional Neuroscience·L K FischerJ R Galler
Apr 17, 2008·European Journal of Pharmacology·Viviana TrezzaLouk J M J Vanderschuren
Mar 30, 2010·Journal of Neuroscience Methods·Ming-Wen ChangMao-Tsun Lin
Jun 28, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Stéphanie DegrooteLarissa Takser
Jul 30, 2003·Genes, Brain, and Behavior·I Branchi, L Ricceri
Feb 14, 1998·Toxicology and Industrial Health·E AllevaD Santucci
Jan 30, 2018·Nutritional Neuroscience·Tatiane Helena BatistaFabiana Cardoso Vilela
Aug 22, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Aldina VenerosiEnrico Alleva
Sep 19, 2003·Toxicology and Applied Pharmacology·Laura RicceriGemma Calamandrei

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.