Economics of Beta-Cell Replacement Therapy

Current Diabetes Reports
Cátia BandeirasRobert A Gabbay

Abstract

Type 1 diabetes impacts 1.3 million people in the USA with a total direct lifetime medical cost of $133.7 billion. Management requires a mix of daily exogenous insulin administration and frequent glucose monitoring. Decision-making by the individual can be burdensome. Beta-cell replacement, which involves devices protecting cells from autoimmunity and allo-rejection, aims at restoring physiological glucose regulation and improving clinical outcomes in patients. Given the significant burden of T1D in the healthcare systems, cost-effectiveness analyses can drive innovation and policymaking in the area. This review presents the health economics analyses performed for donor-derived islet transplantation and the possible outcomes of stem cell-derived beta cells. Long-term cost-effectiveness of islet transplantation depends on the engraftment of these transplants, and the expenses and thresholds assumed by healthcare systems in different countries. Early health technology assessment analyses for stem cell-derived beta-cell replacement suggest manufacturing optimization is necessary to reduce upfront costs.

References

Jan 25, 2003·Health Policy·David Banta
Feb 18, 2011·Clinical Transplantation·Jessica BeckwithHenk-Jan Schuurman
Oct 11, 2014·Cell·Felicia W PagliucaDouglas A Melton
Sep 30, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Natalie M MountJohan Hyllner
Oct 4, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D C BrennanP J Bianchine
Nov 26, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S MoassesfarA M Posselt
Dec 15, 2015·Pancreas·Alan C FarneyEmmanuel C Opara
May 11, 2016·Nature Communications·Jeffrey R MillmanDouglas A Melton
Nov 12, 2016·Nature Reviews. Endocrinology·A M James ShapiroCamillo Ricordi
Nov 20, 2016·Clinical Transplantation·Simen W SchiveHanne Scholz
Feb 16, 2017·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Y SawaT Yamaoka
Jul 26, 2017·Current Diabetes Reports·Laura N McEwenWilliam H Herman
Dec 2, 2017·Endocrine Connections·Stavroula A PaschouChristina Kanaka-Gantenbein
Feb 1, 2018·BMC Endocrine Disorders·Klemens WallnerChristopher McCabe
Feb 3, 2018·Islets·Anissa GambleA M James Shapiro
Mar 3, 2018·Diabetes Research and Clinical Practice·N H ChoB Malanda
Mar 24, 2018·Diabetes Care·UNKNOWN American Diabetes Association
Mar 30, 2018·MMWR. Morbidity and Mortality Weekly Report·Kai McKeever BullardGiuseppina Imperatore
May 21, 2018·PharmacoEconomics·Arthur E AttemaKarl Claxton
Jun 13, 2018·Journal of Clinical Nursing·Teresa Connolly, Ellen Mahoney
Jun 18, 2018·Current Diabetes Reports·Albert J Hwa, Gordon C Weir
Jul 7, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Lara C Pullen
Jul 15, 2018·Clinical Therapeutics·Christopher-Paul Milne, Kenneth I Kaitin
Jul 31, 2018·Frontiers in Medicine·Rita BottinoMassimo M Trucco
Oct 12, 2018·Physiology·Rangarajan SambathkumarMaria Cristina Nostro
Jan 31, 2019·Annals of Gastroenterological Surgery·Takayuki AnazawaShinji Uemoto

❮ Previous
Next ❯

Citations

Mar 3, 2020·Frontiers in Veterinary Science·Suryo KuncorojaktiChenphop Sawangmake
Feb 25, 2021·Regenerative Medicine·Satsuki YamadaAndre Terzic
Mar 6, 2021·Molecular and Cellular Biochemistry·Carla P Barragán-ÁlvarezNestor E Díaz-Martínez
Mar 16, 2021·Frontiers in Endocrinology·Eleonora de Klerk, Matthias Hebrok
Aug 14, 2021·Stem Cells Translational Medicine·Diepiriye G IworimaTimothy J Kieffer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.