Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites

Chemosphere
Radka ZounkováWolfgang Dott

Abstract

In spite of growing scientific concern about pharmaceuticals in the environment, there is still a lack of information especially with regard to their metabolites. The present study investigated ecotoxicity and genotoxicity of three widely used cytostatic agents 5-fluorouracil (5-FU), cytarabine (CYT) and gemcitabine (GemC) and their major human metabolites, i.e. alpha-fluoro-beta-alanine (FBAL), uracil-1-beta-D-arabinofuranoside (AraU) and 2',2'-difluorodeoxyuridine (dFdU), respectively. Effects were studied in acute immobilization and reproduction assays with crustacean Daphnia magna and growth inhibition tests with alga Desmodesmus subspicatus and bacteria Pseudomonas putida. Genotoxicity was tested with umu-test employing Salmonella choleraesius subsp. chol. Toxicity was relatively high at parent compounds with EC(50) values ranging from 44 microg L(-1) (5-fluorouracil in the P. putida test) to 200 mg L(-1) (cytarabine in D. magna acute test). In general, the most toxic compound was 5-FU. Studied metabolites showed low or no toxicity; only FBAL (metabolite of 5-FU) showed low toxicity to D. subspicatus and P. putida with EC(50) values 80 and 140 mg L(-1), respectively. All parent cytostatics showed genotoxicity with minimum ...Continue Reading

References

Oct 1, 1990·The Journal of Pharmacy and Pharmacology·G W AherneA H Nield
Mar 1, 1997·Ecotoxicology and Environmental Safety·T Steger-HartmannA Hartmann
May 7, 1998·Chemosphere·B Halling-SørensenS E Jørgensen
Mar 8, 2000·Chemosphere·L WollenbergerK O Kusk
Mar 5, 2002·Environmental Technology·O A JonesJ N Lester
Aug 7, 2002·Clinical Pharmacokinetics·Akinobu HamadaMasahiro Nakano
Apr 17, 2004·Water Research·Klaus KümmererAlice Schöll
Sep 15, 2004·Analytical and Bioanalytical Chemistry·Susanne N MahnikRobert M Mader
Jul 5, 2005·Chemosphere·Jun HiroseKouichi Sano
Sep 18, 2007·Environmental Toxicology and Chemistry·Radka ZounkováLudek Bláha
Mar 3, 2009·Environment International·Michiel B VandegehuchteColin R Janssen
Jun 3, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M B VandegehuchteC R Janssen

❮ Previous
Next ❯

Citations

Jan 10, 2013·Environmental Science and Pollution Research International·Lubomira KovalovaJuliane Hollender
Jun 14, 2013·Environmental Science & Technology·Lubomira KovalovaChrista S McArdell
Jan 2, 2014·Chemosphere·Jozef KováčikPetr Babula
Mar 15, 2014·Environmental Science and Pollution Research International·Pravin K Mutiyar, Atul K Mittal
Feb 12, 2014·Chemosphere·Alfredo ParrellaMarina Isidori
Mar 23, 2011·The Science of the Total Environment·Raphaela OsterauerHeinz-R Köhler
Apr 3, 2013·The Science of the Total Environment·Frédéric Orias, Yves Perrodin
Sep 24, 2015·Environmental Science and Pollution Research International·Matjaž NovakMetka Filipič
Feb 28, 2015·Environmental Research·Helena Franquet-GriellSilvia Lacorte
Dec 27, 2013·The Science of the Total Environment·Victoria BookerRichard Williams
May 7, 2015·Environmental Science and Pollution Research International·Goran GajskiMetka Filipič
Mar 29, 2014·The Science of the Total Environment·Noelia NegreiraDamià Barceló
Nov 10, 2013·Water Research·Hank Hui-Hsiang Lin, Angela Yu-Chen Lin
Apr 15, 2014·The Science of the Total Environment·Alfredo ParrellaMarina Isidori
May 18, 2016·Marine Environmental Research·Chiara TrombiniMaria João Bebianno
May 11, 2016·Genome Biology·Bernadett SzikrisztDávid Szüts
May 31, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jun IshidaYonson Ku
Jul 17, 2016·Ecotoxicology and Environmental Safety·Marina IsidoriLuděk Bláha
May 2, 2014·Ecotoxicology and Environmental Safety·Marko GerićVera Garaj-Vrhovac
Jan 18, 2018·Arhiv za higijenu rada i toksikologiju·Susana ViegasGoran Gajski
Oct 5, 2018·Arhiv za higijenu rada i toksikologiju·Susana ViegasMário Pádua
Feb 2, 2019·Environmental Science and Pollution Research International·Jyoti RanjanDalia Dasgupta Mandal
Jan 29, 2020·Journal of Toxicology and Environmental Health. Part a·Wenzhi BaiTakashi Kubo
May 30, 2019·International Journal of Molecular Sciences·Krystian Miazek, Beata Brozek-Pluska
Nov 1, 2020·The Science of the Total Environment·Angelika TkaczykBrygida Ślaska
Dec 29, 2020·Journal of Hazardous Materials·Marcelina JureczkoKarolina Rudnicka
Feb 3, 2021·Environmental Science and Pollution Research International·Jyoti RanjanDalia Dasgupta Mandal
Aug 25, 2021·The Science of the Total Environment·Carla NassourJames Barker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.