Ecotoxicological equilibria of triclosan in Microtox, XenoScreen YES/YAS, Caco2, HEPG2 and liposomal systems are affected by the occurrence of other pharmaceutical and personal care emerging contaminants

The Science of the Total Environment
Miquel OliverManuel Miró

Abstract

Contaminants of emerging concern may be considered as any chemicals or factors whose unintended continuous release and persistence in the environment may lead to any observable undesirable response of living beings. Still not much is known on reciprocal toxicological impact of given chemicals when present in binary or more complex mixtures. In this work, an attempt was thus undertaken to study the impact of butylparaben, methylparaben and diclofenac on toxicological behavior and properties of triclosan (at varying concentration levels) with respect to Microtox, XenoScreen YES/YAS, Caco-2, HEPG2, and liposomal systems. Having performed analytical and biological studies modeling was done using two modeling approaches, viz., concentration addition (CA) and independent action (IA) at three concentration levels of each chemical studied. The effect of the highest concentration of triclosan studied was impacted by even small amounts of methylparaben and butylparaben in Microtox while diclofenac preferably affected triclosan activity at its lowest concentration level (with CA model). Estrogenic agonistic properties of triclosan were severely impacted by both parabens in an antagonistic way; diclofenac showed in all cases underestimatio...Continue Reading

Citations

Apr 18, 2021·Analytica Chimica Acta·Francisco Pena-PereiraElefteria Psillakis

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