Ecotoxicological evaluation of chlorpyrifos exposure on the nematode Caenorhabditis elegans

Ecotoxicology and Environmental Safety
Ji-Yeon Roh, Jinhee Choi

Abstract

To investigate the effects of chlorpyrifos (CP), an organophosphorus insecticide, on the soil nematode Caenorhabditis elegans, the toxicity of the insecticide on the molecular, biochemical, and physiological levels were investigated upon sublethal exposure, and an acute toxicity test was conducted using lethality as an endpoint. To assess the molecular-level effect, stress-related gene expression was investigated, and the neurotoxicity indicator, acetylcholinesterase (AChE) activity was assessed as the biochemical-level response. Growth, reproduction and development were also studied as physiological-level responses. The overall results indicate that CP exposure leads to the alteration of the expression of some stress genes, such as of heat shock protein, metallothionein, vitellogenin and C. elegans p53-like protein genes; the inhibition of AChE activity; and the retardation of development. These data suggest that the toxicity of CP on C. elegans occurred in multiple biological organizations; nevertheless this is not sufficient to conclude that there is a casual relationship between them. Thus, direct experimental demonstrations of the wider relationships between the molecular/biochemical effects of CP exposure and their conseq...Continue Reading

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Citations

Sep 8, 2012·Environmental Science and Pollution Research International·Jingjuan JuDayong Wang
May 21, 2013·Ecotoxicology and Environmental Safety·Bhadravathi Chandrappa Leelaja, Padmanabhan Sharda Rajini
Jun 28, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Danielle HagstromEva-Maria S Collins
Sep 11, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Dean Meyer, Phillip L Williams
Jun 6, 2009·Journal of Toxicology and Environmental Health. Part a·Qin-Li RuanDa-Yong Wang
Aug 9, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Martina HöcknerStephen R Stürzenbaum
Dec 18, 2020·Frontiers in Genetics·Biswapriya B Misra
Apr 22, 2020·Environmental Science and Pollution Research International·Tanita PescatoreAnna Barra Caracciolo

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