Ecotropic Murine Leukemia Virus Infection of Glial Progenitors Interferes with Oligodendrocyte Differentiation: Implications for Neurovirulence

Journal of Virology
Ying LiWilliam P Lynch

Abstract

Certain murine leukemia viruses (MLVs) are capable of inducing fatal progressive spongiform motor neuron disease in mice that is largely mediated by viral Env glycoprotein expression within central nervous system (CNS) glia. While the etiologic mechanisms and the glial subtypes involved remain unresolved, infection of NG2 glia was recently observed to correlate spatially and temporally with altered neuronal physiology and spongiogenesis. Since one role of NG2 cells is to serve as oligodendrocyte (OL) progenitor cells (OPCs), we examined here whether their infection by neurovirulent (FrCasE) or nonneurovirulent (Fr57E) ecotropic MLVs influenced their viability and/or differentiation. Here, we demonstrate that OPCs, but not OLs, are major CNS targets of both FrCasE and Fr57E. We also show that MLV infection of neural progenitor cells (NPCs) in culture did not affect survival, proliferation, or OPC progenitor marker expression but suppressed certain glial differentiation markers. Assessment of glial differentiation in vivo using transplanted transgenic NPCs showed that, while MLVs did not affect cellular engraftment or survival, they did inhibit OL differentiation, irrespective of MLV neurovirulence. In addition, in chimeric brain...Continue Reading

References

Jan 1, 1976·Cold Spring Harbor Symposia on Quantitative Biology·M J DowdallH Zimmermann
Jul 1, 1977·Journal of the National Cancer Institute·J A McCarterJ V Frei
Oct 1, 1973·Journal of the National Cancer Institute·M B GardnerR J Huebner
Apr 1, 1974·Journal of Neuropathology and Experimental Neurology·J M Andrews, M B Gardner
Dec 1, 1993·Experimental Neurology·R M NagraC A Wiley
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D G KayP Jolicoeur
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·C MünkC Stocking
Nov 24, 1999·Journal of Neuropathology and Experimental Neurology·A NishiyamaB D Trapp
Dec 10, 1999·Journal of Virology·S AskovićJ L Portis
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·E D LaywellD A Steindler
Oct 24, 2003·Molecular and Cellular Neurosciences·Mary R L DawsonRichard Reynolds
Dec 22, 2005·Journal of Anatomy·Arthur M ButtMerdol Ibrahim
May 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Keith L LigonDavid H Rowitch
Aug 29, 2006·The American Journal of Pathology·Amanda C ClaseJohn L Portis
Sep 18, 2007·Genesis : the Journal of Genetics and Development·Mandar Deepak MuzumdarLiqun Luo
Nov 30, 2007·Development·Xiaoqin ZhuAkiko Nishiyama
Mar 4, 2008·Nature Neuroscience·Ragnhildur KáradóttirDavid Attwell
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leda DimouMagdalena Götz
Nov 14, 2008·Neuron Glia Biology·Xiaoqin ZhuAkiko Nishiyama
Dec 6, 2008·The Journal of Comparative Neurology·Mila KomitovaAkiko Nishiyama
Dec 20, 2008·Nature Reviews. Neuroscience·Akiko NishiyamaXiaoqin Zhu

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.