PMID: 910Nov 1, 1975

ECS, intracellular pH, and electrolytes of cardiac and skeletal muscle

The American Journal of Physiology
P A Poole-Wilson, I R Cameron

Abstract

The extracellular space (ECS) of muscle from each ventricle of the heart (RV and LV), the atria, diaphragm, and quadriceps was estimated in the anesthetized rabbit from the distribution volumes of [14C]insulin, [14C]sucrose, [51Cr]EDTA, and C1--. Whole-tissue electrolytes were measured and intracellular electrolytes calculated. The ECS of the tissues varied, increasing in the order quadriceps less than LV less than RV less than atria. The volume of distribution of [14C]inulin was always less than that of either [14C]sucrose or [51Cr]EDTA which agreed closely, whereas that of C1-- was always greater. There was no difference in intracellular K+ in muscle from each of the cardiac chambers, whereas intracellular Na+ and C1-- varied, increasing in the order quadriceps less than LV less than RV less than atria. Intracellular pH, measured with [14C]DMO did not differ in any of the tissues studied. It is concluded that, in vivo, the estimated ECS incardiac muscle is lower than that reported in vitro, that [51Cr]EDTA is a satisfactory ECS marker, and that differences in intracellular Na+ and C1-- but not K+ or pH exist between muscle from the cardiac chambers.

Citations

Jan 1, 1986·Annals of the New York Academy of Sciences·M W Bradbury, R Deane
Nov 1, 1982·Archives internationales de physiologie et de biochimie·V CappelliL Ricciardi
Jul 1, 1988·Acta Physiologica Scandinavica·S KeidingP Sejrsen
Aug 2, 2003·BMC Clinical Pharmacology·David G Levitt
Sep 25, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Brian K PanamaAnatoli N Lopatin
Nov 1, 1979·Basic Research in Cardiology·P A Poole-WilsonD P Harding
Apr 1, 1987·Pflügers Archiv : European journal of physiology·M MacDermott
Nov 1, 1990·Acta Physiologica Scandinavica·F R AndersenA Ilebekk
Mar 17, 1999·Journal of Magnetic Resonance Imaging : JMRI·J P ValléeD Didier
Jun 1, 1983·Acta Physiologica Scandinavica·H HagbergH Haljamäe

Related Concepts

Body Water
Chloride Ion Level
Respiratory Diaphragm
Extracellular Space
Hydrogen-Ion Concentration
Intracellular Fluid
Muscle
Myocardium
Potassium
Sodium

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