Ecstasy-induced brain death and acute hepatocellular failure: multiorgan donor and liver transplantation

Francisco CaballeroGabriel Txoperena


Ecstasy is a neurotoxic and hepatotoxic drug. Brain edema and fulminant hepatic failure are two of the most serious complications associated with the consumption of ecstasy. Acute ecstasy intoxication can transform a patient into an organ donor or a hepatic graft recipient. In the last 5 years in our centers, we have had two multiorgan donors who died from ecstasy-induced brain edema and three patients who required urgent orthotopic liver transplantation for treatment of severe acute hepatocellular failure induced by this drug. We performed eight transplantations using the organs of these two brain-dead donors: one heart, one bipulmonary, three kidneys, one kidney-pancreas, and two livers. Toxicity caused by ecstasy was not observed in any of the eight patients who underwent transplantation. The clinical state and the graft function of the heart, two liver, renopancreatic, and three kidney recipients were normal for a follow-up period that ranged between 7 months and 4.5 years. The lung recipient died from multiorgan failure secondary to bilateral pneumonia 5 days after the transplantation, and one of the kidney transplant patients died as a result of intestinal lymphoma 6 months after transplantation. The three liver transplan...Continue Reading


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Related Concepts

Irreversible Coma
Tissue Donors
Heart Transplantation
Kidney Transplantation
Transplantation of Liver
Pancreas Transplantation
Lung Transplantation
Liver Failure
N-Methyl-3,4-methylenedioxyamphetamine Hydrochloride

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