Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia

Neuroscience
João Paulo CapelaFélix Carvalho

Abstract

Studies on 3,4-methylenedioxymethamphetamine ("ecstasy")-induced neurotoxicity mainly focus on damage of serotonergic terminals. Less attention has been given to neuronal cell death produced by 3,4-methylenedioxymethamphetamine and other amphetamines in areas including the cortex, striatum and thalamus. In the present study we investigated 3,4-methylenedioxymethamphetamine-induced neurotoxicity in neuronal serum free cultures from rat cortex. Since 3,4-methylenedioxymethamphetamine intake induces hyperthermia in both animals and humans, the experiments were performed under normal (36.5 degrees C) and hyperthermic conditions (40 degrees C). Our findings showed a dose-, time- and temperature-dependent apoptotic cell death induced by 3,4-methylenedioxymethamphetamine in cortical neurons. 3,4-Methylenedioxymethamphetamine-induced damage was potentiated under hyperthermia. The neurotoxicity was reduced by the serotonin 2A-receptor antagonists, ketanserin and (2R,4R)-5-[2-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]ethyl]-1-methyl-3-pyrrolidinol hydrochloride, in both normothermic and hyperthermic conditions. (+/-)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride, a model agonist for the serotonin 2A-receptor, also induced a dose- and time-dep...Continue Reading

References

Jul 4, 1992·BMJ : British Medical Journal·J A Henry
Nov 1, 1992·Journal of Neurochemistry·B Halliwell
Jan 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H Y KilC A Piantadosi
Apr 12, 2000·Brain Research Bulletin·T Xu, S C Pandey
Feb 19, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Liesbeth RenemanJan Booij
Jul 19, 2003·Pharmacological Reviews·A Richard GreenM Isabel Colado
Aug 21, 2003·Forensic Science International : Synergy·R García-RepettoM Menéndez
Jan 22, 2004·Psychopharmacology·Elizabeth Anne JohnsonDiane B Miller

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Citations

Mar 7, 2012·Archives of Toxicology·Márcia CarvalhoMaria de Lourdes Bastos
Jun 23, 2009·Cellular and Molecular Neurobiology·Anna M S Kindlundh-HögbergAsa Fex Svenningsen
Apr 18, 2009·Molecular Neurobiology·João Paulo CapelaFélix Carvalho
Jun 3, 2011·Cell Death & Disease·W Boehmerle, M Endres
May 17, 2008·Cancer Research·Coimbatore S SreevidyaStephen E Ullrich
Nov 2, 2013·Archives of Toxicology·Daniel José BarbosaFélix Carvalho
May 28, 2013·Journal of Toxicology·João Barbosa MartinsJoão Paulo Capela
Feb 14, 2014·Archives of Toxicology·Daniel José BarbosaEduardo Soriano
Dec 1, 2012·Toxicology Letters·Patrícia Silva FerreiraJoão Paulo Capela
Jun 4, 2008·European Journal of Pharmacology·João Paulo CapelaAndreas Meisel
Apr 29, 2008·Brain Research Reviews·Teresa Cunha-OliveiraCatarina R Oliveira
Feb 19, 2008·Brain, Behavior, and Immunity·Daniel A NelsonKenneth L Bost
Jun 19, 2007·Neurotoxicology·João Paulo CapelaFélix Carvalho
May 1, 2007·Neuroscience·J P CapelaF Carvalho
Oct 13, 2015·Progress in Neurobiology·Rosario MoratallaMicaela Morelli
Jul 1, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sónia AbadAntonio Camins
Apr 16, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sónia SilvaMaria Dulce Cotrim
Sep 18, 2012·Neurotoxicology·João Paulo CapelaFélix Carvalho
Dec 9, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Armanda Teixeira-GomesJoão Paulo Capela
Sep 18, 2013·Journal of Korean Neurosurgical Society·Muhammet Bahadır YılmazMemduh Kaymaz
Mar 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Yunhong ZhangJeffrey M Gidday
Oct 18, 2008·Physiology·Tamer Rabie, Hugo H Marti
Mar 30, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Aram B CholaniansTerrence J Monks
Jan 10, 2018·Medicinal Research Reviews·Přemysl MladěnkaUNKNOWN TOX-OER and CARDIOTOX Hradec Králové Researchers and Collaborators
Jan 24, 2020·Cell Death & Disease·Petra HuehnchenMatthias Endres

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