ECT, rTMS, and deepTMS in pharmacoresistant drug-free patients with unipolar depression: a comparative review.

Neuropsychiatric Disease and Treatment
Amedeo MinichinoMassimo Biondi

Abstract

Biological treatments are considered as additional options for the treatment of resistant unipolar depression. Controversial data exist about the efficacy and tolerability of three of the most used somatic treatments: electroconvulsive therapy (ECT), transcranial magnetic stimulation (rTMS), and deep transcranial magnetic stimulation (deepTMS). The aim of this review is to investigate and compare the efficacy and tolerability of these three techniques in drug-free patients with pharmacoresistant unipolar depression. Three independent reviewers extracted data and assessed the quality of methodological reporting of selected studies. The first outcome was the clinical response to the three different techniques defined as a percentage improvement of Hamilton Depression Rating Scale (HDRS). The second outcome was the evaluation of their neuropsychological effects. The third outcome was the evaluation of the number of remitted patients; remission was defined as an absolute HDRS-24 score of ≤11 or as an absolute HDRS-17 score of ≤8. Tolerability was the fourth outcome; it was evaluated by examining the number of dropped-out patients. The comparative evaluation of HDRS percentage variations shows ECT as the most effective method after ...Continue Reading

Citations

Feb 2, 2016·Journal of Psychiatric Research·Karina Karolina KedziorMarcelo T Berlim
Jul 16, 2014·Neural Plasticity·Massimo SalviatiGiancarlo Cianfrone
Jul 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurLuis Garcia-Larrea
Jul 31, 2013·Journal of Affective Disorders·Chris BaekenRudi De Raedt
May 9, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·F S BersaniM Biondi

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