DOI: 10.1101/496026Dec 14, 2018Paper

ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer

BioRxiv : the Preprint Server for Biology
Avais M DaulatF Bertucci


Background: Triple-negative breast cancers are poor-prognosis tumors characterized by absence of molecular signature and are chemotherapy is still the only systemic treatment. Currently, research focus to identify biomarkers that may be usable for prognosis and/or for treatment, notably among the proteins involved in cell migration and metastatic capacity. Methods: We used proteomic approach to identify protein complexes associated to PRICKLE1 and the mRNA expression level of the corresponding genes in a retrospective series of 8,982 clinically annotated patients with invasive primary breast cancer were assessed. Then, we characterize molecularly the interaction between PRICKLE1 and the guanine nucleotide exchange factor ECT2. Finally, experiments in Xenopus have been carrying out to determine their evolutionary conserved interaction. Results: We have identified a network of proteins interacting with the prometastatic scaffold protein PRICKLE1 that includes several small G-protein regulators involved in cell migration and metastasis. Combined analysis expression of PRICKLE1 and small G-protein regulators expression has a strong prognostic value in TNBC. We show that PRICKLE1 controls the activity of ECT2 on RAC1 signaling, a pa...Continue Reading

Related Concepts

Biological Markers
Neoplasm Metastasis
Xenopus laevis
Guanine Nucleotide Exchange Factors
Rac1 GTP-Binding Protein
Benign Epithelioma

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