Ectodermal stimulation of the production of hyaluronan-dependent pericellular matrix by embryonic limb mesodermal cells

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Cheryl B KnudsonB P Toole

Abstract

Interaction of ectoderm and underlying mesoderm is essential for normal vertebrate limb morphogenesis. One of the functions of limb bud ectoderm is its influence on the composition of extracellular matrix in subectodermal mesoderm, which in turn participates in morphogenesis of this region of the limb. This matrix is highly enriched in hyaluronan, even at the time when the level of hyaluronan in the chondrogenic and myogenic regions of the limb decreases, due to secretion of a stimulatory factor by the ectoderm. In this study we show that limb bud ectoderm not only stimulates hyaluronan synthesis but induces formation of large hyaluronan-dependent, pericellular matrices around cultured limb bud mesodermal cells. The ectodermal activity is mimicked in great part by fibroblast growth factor-2 and transforming growth factor-beta, and antibodies to these proteins inhibit induction of mesodermal pericellular matrix by the ectodermal factor. It has been shown by other investigators that fibroblast growth factor-2 is produced by limb ectoderm whereas transforming growth factor-2 is produced by limb ectoderm whereas transforming growth factor-beta is present in limb mesodermal tissues. Thus we conclude that the unique properties of mes...Continue Reading

References

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Citations

Jun 1, 1997·Cytokine & Growth Factor Reviews·H G Wisniewski, J Vilcek
Oct 5, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ghada A Nofal, Cheryl B Knudson
Apr 29, 1998·Microscopy Research and Technique·S TeiR M Farnesi
Mar 15, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Janet Y L Tien, Andrew P Spicer
Jan 21, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E KavanaghA A Pitsillides
Sep 6, 2003·Birth Defects Research. Part C, Embryo Today : Reviews·Cheryl B Knudson
May 26, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C HealyP T Sharpe
Jan 5, 2008·The Journal of Biological Chemistry·Soma MeranAled O Phillips
Oct 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Q YuB P Toole
Jul 6, 2007·The Journal of Biological Chemistry·Soma MeranRobert Steadman

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