Ectopic ACTH-syndrome due to ovarian carcinoma

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
M OrbetzovaG Dashev

Abstract

The case of a 60-year-old female with severe and rapidly progressing Cushing's syndrome with fatal consequences is described. Both the clinical and the biochemical findings were consistent with ectopic ACTH production. A computed tomographic (CT) scan revealed intact pituitary and enlarged adrenal glands. Liver metastases were seen but the primary neoplasm was not found. Treatment with aminoglutethimide and other therapeutic measures were unsuccessful. A carcinoma of the right ovary was discovered on autopsy. The tumour cells showed immunoreactivity for neuron-specific enolase (NSE), ACTH and beta-endorphin with differing degree of intensity.

Citations

Jun 12, 2002·Endocrinology and Metabolism Clinics of North America·Felix Beuschlein, Gary D Hammer
Apr 29, 2006·BMC Cancer·Mathias FasshauerChristian A Koch
May 28, 2002·Journal of Endocrinological Investigation·K SworczakA Lewczuk
Jan 9, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Baoyou HuangFeiyun Zheng
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maryam I KhanCamilo Jimenez
Apr 25, 2012·Annals of the Royal College of Surgeons of England·I SenV Sitaram
Nov 8, 2012·Annals of the Royal College of Surgeons of England·N MashooriA R Kazemeini
Apr 12, 2014·Hormones : International Journal of Endocrinology and Metabolism·Eftekhar H Al Ojaimi

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