PMID: 9189820Jun 15, 1997Paper

Ectopic bone induction in porous apatite-wollastonite-containing glass ceramic combined with bone morphogenetic protein

Journal of Biomedical Materials Research
S IjiriS Komatsudani

Abstract

To accelerate the integration of ceramic implants with the surrounding bone and to search for a suitable carrier for bone morphogenetic protein (BMP), we studied ectopic bone induction in porous apatite-wollastonite-containing glass ceramic (A-W GC) combined with partially purified bovine BMP (bBMP) and recombinant Xenopus BMP-4/7 (rxBMP-4/7). Porous A-W GC rods [4 mm in diameter, 5 mm in height, 70% porosity, 200 microns mean pore size, 17.54 +/- 3.82 MPa (mean +/- SD) compressive strength] were used. An apatite coating formed on the surface of porous A-W GC that had been immersed in simulated body fluid at 36.5 degrees C for 7 days. In experiment 1, porous A-W GC rods were combined with either bBMP, collagen, or with both bBMP and collagen. The rods were implanted into subcutaneous pouches in rats and were harvested 4 weeks after implantation. Low-energy radiographic, scanning electron microscopic (SEM), and histological examinations showed ectopic bone formation and within the rods only in the porous A-W GC combined with the bBMP and collagen group. Quantitative analysis also revealed that this group alone showed a significant increase in bone formation. In experiment 2, porous A-W GC rods were combined with rxBMP and collag...Continue Reading

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Citations

Oct 17, 1998·Journal of Biomedical Materials Research·W Q YanT Nakamura
Jul 9, 1999·Journal of Biomedical Materials Research·C DuK de Groot
Jun 24, 1999·Journal of Biomedical Materials Research·H B WenK de Groot
Mar 29, 2000·Journal of Biomedical Materials Research·Y SuzukiY Nishimura
Jun 20, 2001·Trends in Biotechnology·R H Li, J M Wozney
Sep 1, 2000·Advanced Drug Delivery Reviews·C A Kirker-Head
Sep 6, 2000·Journal of Periodontology·Z SchwartzB D Boyan
Jun 5, 2003·Expert Opinion on Biological Therapy·Julie A JadlowiecJeffrey O Hollinger
May 3, 2016·Indian Journal of Dentistry·Supreet KaurRanjan Malhotra
Nov 6, 1998·International Journal of Oral and Maxillofacial Surgery·M MurataN Nagai
Nov 15, 2001·Journal of Dental Research·N C TengK Yamashita
Jan 25, 2005·Journal of Biomedical Materials Research. Part a·R RohanizadehA Bendavid

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