Ectopic cushing's syndrome caused by an 8 mm lung carcinoid localized by scintigram with the somatostatin analog111 in-pentetreotide

Endocrine Pathology
João Filipe RaposoKaiman Kovacs

Abstract

Small tumors producing adrenocorticophic hormone (ACTH) ectopically may be very difficult to locate. We describe a 57-year-old woman who presented with ectopic Cushing's syndrome as diagnosed by bilateral inferior petrosal sinus catheterization with corticotrophin-releasing hormone (CRH) test. Thoracic pentetreotide (a somatostatin analogue) revealed a small "hot spot" in the base of the left lung. This "hot spot" was constant throughout the procedure. A second thoracic CT scan with 3-mm cuts showed a small image in the area under suspicion, similar to vascular images found elsewhere in both lungs. At surgery, an 8-mm tumor was found and excised. Pathological examination revealed a carcinoid tumor immunoreactive for ACTH, beta-endorphin, bombesin, serotonin, and the α-subunit. One month after surgery, the patient was clinically well and had normal adrenal function. An111ln-pentetreotide scintiscan clearly identified a small ACTH-producing neuroendocrine tumor of the lung undetectable by plain chest radiography or CT scan.

References

Aug 1, 1992·Annals of Internal Medicine·A H LimperB A Staats
Nov 1, 1990·The New England Journal of Medicine·S W LambertsE P Krenning
Nov 1, 1990·The New England Journal of Medicine·Y C Patel
Feb 28, 1989·European Journal of Pharmacology·T P DavisR H Liu
Dec 1, 1987·The Journal of Clinical Endocrinology and Metabolism·U KniggeP Bang
Nov 1, 1985·Clinics in Endocrinology and Metabolism·T A HowlettG M Besser
Mar 1, 1987·Radiology·S C SarisE H Oldfield
Jan 15, 1981·The New England Journal of Medicine·G N BurrowK Kovacs
Aug 1, 1993·Clinical Endocrinology·A White, A J Clark
May 13, 1993·The New England Journal of Medicine·S E Weinberger
May 1, 1993·Trends in Endocrinology and Metabolism : TEM·P G McNally, T A Howlett

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