Ectopic Cushing's syndrome secondary to lung and mediastinal tumours -- report from a tertiary care centre in Iran

Endokrynologia Polska
Ali A GhaziMarina Pourafkari

Abstract

Ectopic Cushing`s syndrome (ECS) secondary to neuroendocrine tumours (NETs) of the lung and mediastinum are rarely encountered. In this study, we present our experience in Iran on 15 patients with ECS secondary to lung and mediastinal tumours over a period of 27 years. Since 1985, 15 patients with ECS secondary to lung and mediastinal tumours have been diagnosed and prospectively followed by the endocrinology team of Taleghani Hospital, Tehran, Iran. The clinical signs and symptoms, laboratory findings, radiological features, immunohistochemical characteristics, management strategies and outcome data are here presented. There were six women and nine men, aged 26-70 years, all presenting with typical features of Cushing's syndrome. Based on histopathologic evaluations, four patients had small cell lung cancer (SCLC) and seven patients had pulmonary NETs, one patient had a thymic NET, and one case was diagnosed as a lung tumourlet. The mean ± SD serum cortisol, 24h urine free cortisol and plasma ACTH were 47.2 ± 20.5 μg/dL, 2,702 ± 5,439 μg/day, and 220 ± 147 pg/mL, respectively. Pulmonary lesions ranged in diameter from 1.1 to 4 cm (mean 1.9 ± 1.1 cm). One patient had a 10 cm mediastinal mass. The duration of follow up in these ...Continue Reading

Citations

Oct 31, 2019·The Journal of Clinical Endocrinology and Metabolism·German RubinsteinMartin Reincke
May 2, 2019·Pituitary·Manouchehr NakhjavaniAli A Ghazi
Jul 2, 2020·Archives of Endocrinology and Metabolism·Vanessa Lopez-MontoyaCamilo Jimenez
May 17, 2018·Pituitary·Marta Araujo Castro, Mónica Marazuela Azpiroz
May 26, 2021·Archives of Endocrinology and Metabolism·Vanessa Lopez-MontoyaCamilo Jimenez

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