Ectopic expression of cyclin D1 impairs the proliferation and enhances the apoptosis of a murine lymphoid cell line

Cell Death and Differentiation
F DuquesneB Sola

Abstract

Cyclin D1, a key regulator of the cell cycle, acts as an oncogene when over-expressed in several types of cancer. In some B-chronic lymphoproliferative disorders, the over-expression of cyclin D1 protein is thought to confer a proliferative phenotype. We have generated BaF3 pro-B cell derivatives in which cyclin D1 can be induced rapidly and reversibly in a dose-dependent manner by the hormone muristerone A. When non-expressing clones displayed the same proliferative capacity as the parental cell line, in the sub-clones, a moderate induction of cyclin D1 lengthened the proliferation rate. The over-expression of cyclin D1 had the same effects on cell proliferation but also led ultimately to cell death by apoptosis. The induction of cyclin D1 in growth factor-deprived cells as well as in anticancer drug-treated cells also reinforced the magnitude of apoptosis. Thus, the expression of cyclin D1 in lymphoid cells does not confer a proliferative advantage but rather alters the response of cells towards apoptotic stimuli in a p53-independent manner.

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Citations

Sep 11, 2003·Journal of Hematotherapy & Stem Cell Research·Gurveen SaberwalSuneel D Mundle
May 15, 2007·Experimental Cell Research·Céline LévêqueBrigitte Sola
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Denis LesageBrigitte Sola
Apr 2, 2016·Nature Reviews. Molecular Cell Biology·Per HydbringPiotr Sicinski
Jun 15, 2013·Current Opinion in Immunology·Julie S Lefebvre, Laura Haynes
Jun 22, 2019·Chemistry & Biodiversity·Başak AruHasan Kırmızıbekmez
Nov 19, 2003·Blood·Brigitte Sola, Xavier Troussard
Apr 14, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rui E CastroCecília M P Rodrigues

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