Ectopic expression of serotonin7 receptors in an adrenocortical carcinoma co-secreting renin and cortisol

Endocrine-related Cancer
Estelle LouisetHervé Lefebvre

Abstract

Abnormal expression of membrane receptors has been previously described in benign adrenocortical neoplasms causing Cushing's syndrome. In particular, we have observed that, in some adreno corticotropic hormone (ACTH)-independent macronodular adrenal hyperplasia tissues, cortisol secretion is controlled by ectopic serotonin(7) (5-HT(7)) receptors. The objective of the present study was to investigate in vitro the effect of serotonin (5-hydroxy tryptamine; 5-HT) on cortisol and renin production by a left adrenocortical carcinoma removed from a 48-year-old female patient with severe Cushing's syndrome and elevated plasma renin levels. Tumor explants were obtained at surgery and processed for immunohistochemistry, in situ hybridization and cell culture studies. 5-HT-like immunoreactivity was observed in mast cells and steroidogenic cells disseminated in the tissue. 5-HT stimulated cortisol release by cultured cells. The stimulatory effect of 5-HT on cortisol secretion was suppressed by the 5-HT(7) receptor antagonist SB269970. In addition, immunohistochemistry showed the occurrence of 5-HT(7) receptor-like immunoreactivity in carcinoma cells. mRNAs encoding renin as well as renin-like immunoreactivity were detected in endothelial a...Continue Reading

Citations

Aug 31, 2010·Actas urologicas españolas·L F AriasJ Blanco
Jul 14, 2010·Pathology, Research and Practice·Luis F AriasJulia Blanco
May 15, 2015·European Journal of Endocrinology·Nada El GhorayebAndré Lacroix
Nov 30, 2014·Molecular and Cellular Endocrinology·H LefebvreE Louiset
Oct 25, 2016·Molecular and Cellular Endocrinology·Estelle LouisetHervé Lefebvre
May 28, 2019·Canadian Journal of Physiology and Pharmacology·Neeshu SarojJosé A Terrón
Mar 27, 2020·OncoTargets and Therapy·Xiaohui DuJungang Xie
Jul 14, 2020·Molecular and Cellular Endocrinology·Shiv ShankerJosé A Terrón

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